The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)

Abstract The ability to regulate food intake is critical to survival. The hypothalamus is central to this regulation, integrating peripheral signals of energy availability. Although our understanding of hunger in rodents is advanced, an equivalent understanding in birds is lacking. In particular, th...

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Autores principales:	J. J. Lees, C. Lindholm, P. Batakis, M. Busscher, J. Altimiras
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4461ec52d85a457da43db534f31fabbd
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spelling	oai:doaj.org-article:4461ec52d85a457da43db534f31fabbd2021-12-02T15:05:16ZThe physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)10.1038/s41598-017-17922-w2045-2322https://doaj.org/article/4461ec52d85a457da43db534f31fabbd2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17922-whttps://doaj.org/toc/2045-2322Abstract The ability to regulate food intake is critical to survival. The hypothalamus is central to this regulation, integrating peripheral signals of energy availability. Although our understanding of hunger in rodents is advanced, an equivalent understanding in birds is lacking. In particular, the relationship between peripheral energy indices and hypothalamic ‘hunger’ peptides, agouti-related protein (AgRP), pro-opiomelanocortin (POMC) and neuropeptide Y (NPY) is poorly understood. Here, we compare AgRP, POMC and NPY RNA levels in the hypothalamus of Red Junglefowl chicks raised under ad libitum, chronic restriction and intermittent feeding regimens. Hypothalamic gene expression differed between chronically and intermittently restricted birds, confirming that different restriction regimens elicit different patterns of hunger. By assessing the relationship between hypothalamic gene expression and carcass traits, we show for the first time in birds that AgRP and POMC are responsive to fat-related measures and therefore represent long-term energy status. Chronically restricted birds, having lower indices of fat, show elevated hunger according to AgRP and POMC. NPY was elevated in intermittently fasted birds during fasting, suggesting a role as a short-term index of hunger. The different physiological and neuroendocrine responses to quantitative versus temporal feed restriction provide novel insights into the divergent roles of avian hunger neuropeptides.J. J. LeesC. LindholmP. BatakisM. BusscherJ. AltimirasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. J. Lees C. Lindholm P. Batakis M. Busscher J. Altimiras The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
description	Abstract The ability to regulate food intake is critical to survival. The hypothalamus is central to this regulation, integrating peripheral signals of energy availability. Although our understanding of hunger in rodents is advanced, an equivalent understanding in birds is lacking. In particular, the relationship between peripheral energy indices and hypothalamic ‘hunger’ peptides, agouti-related protein (AgRP), pro-opiomelanocortin (POMC) and neuropeptide Y (NPY) is poorly understood. Here, we compare AgRP, POMC and NPY RNA levels in the hypothalamus of Red Junglefowl chicks raised under ad libitum, chronic restriction and intermittent feeding regimens. Hypothalamic gene expression differed between chronically and intermittently restricted birds, confirming that different restriction regimens elicit different patterns of hunger. By assessing the relationship between hypothalamic gene expression and carcass traits, we show for the first time in birds that AgRP and POMC are responsive to fat-related measures and therefore represent long-term energy status. Chronically restricted birds, having lower indices of fat, show elevated hunger according to AgRP and POMC. NPY was elevated in intermittently fasted birds during fasting, suggesting a role as a short-term index of hunger. The different physiological and neuroendocrine responses to quantitative versus temporal feed restriction provide novel insights into the divergent roles of avian hunger neuropeptides.
format	article
author	J. J. Lees C. Lindholm P. Batakis M. Busscher J. Altimiras
author_facet	J. J. Lees C. Lindholm P. Batakis M. Busscher J. Altimiras
author_sort	J. J. Lees
title	The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
title_short	The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
title_full	The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
title_fullStr	The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
title_full_unstemmed	The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
title_sort	physiological and neuroendocrine correlates of hunger in the red junglefowl (gallus gallus)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4461ec52d85a457da43db534f31fabbd
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The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)

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