Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network

Abstract Banana, one of the most important staple fruit among global consumers is highly sterile owing to natural parthenocarpy. Identification of genetic factors responsible for parthenocarpy would facilitate the conventional breeders to improve the seeded accessions. We have constructed Protein–pr...

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Autores principales:	Suthanthiram Backiyarani, Rajendran Sasikala, Simeon Sharmiladevi, Subbaraya Uma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4464a55325dd4f688833910e8738a14a
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spelling	oai:doaj.org-article:4464a55325dd4f688833910e8738a14a2021-12-02T16:08:08ZDecoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network10.1038/s41598-021-93661-32045-2322https://doaj.org/article/4464a55325dd4f688833910e8738a14a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93661-3https://doaj.org/toc/2045-2322Abstract Banana, one of the most important staple fruit among global consumers is highly sterile owing to natural parthenocarpy. Identification of genetic factors responsible for parthenocarpy would facilitate the conventional breeders to improve the seeded accessions. We have constructed Protein–protein interaction (PPI) network through mining differentially expressed genes and the genes used for transgenic studies with respect to parthenocarpy. Based on the topological and pathway enrichment analysis of proteins in PPI network, 12 candidate genes were shortlisted. By further validating these candidate genes in seeded and seedless accession of Musa spp. we put forward MaAGL8, MaMADS16, MaGH3.8, MaMADS29, MaRGA1, MaEXPA1, MaGID1C, MaHK2 and MaBAM1 as possible target genes in the study of natural parthenocarpy. In contrary, expression profile of MaACLB-2 and MaZEP is anticipated to highlight the difference in artificially induced and natural parthenocarpy. By exploring the PPI of validated genes from the network, we postulated a putative pathway that bring insights into the significance of cytokinin mediated CLAVATA(CLV)–WUSHEL(WUS) signaling pathway in addition to gibberellin mediated auxin signaling in parthenocarpy. Our analysis is the first attempt to identify candidate genes and to hypothesize a putative mechanism that bridges the gaps in understanding natural parthenocarpy through PPI network.Suthanthiram BackiyaraniRajendran SasikalaSimeon SharmiladeviSubbaraya UmaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suthanthiram Backiyarani Rajendran Sasikala Simeon Sharmiladevi Subbaraya Uma Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network
description	Abstract Banana, one of the most important staple fruit among global consumers is highly sterile owing to natural parthenocarpy. Identification of genetic factors responsible for parthenocarpy would facilitate the conventional breeders to improve the seeded accessions. We have constructed Protein–protein interaction (PPI) network through mining differentially expressed genes and the genes used for transgenic studies with respect to parthenocarpy. Based on the topological and pathway enrichment analysis of proteins in PPI network, 12 candidate genes were shortlisted. By further validating these candidate genes in seeded and seedless accession of Musa spp. we put forward MaAGL8, MaMADS16, MaGH3.8, MaMADS29, MaRGA1, MaEXPA1, MaGID1C, MaHK2 and MaBAM1 as possible target genes in the study of natural parthenocarpy. In contrary, expression profile of MaACLB-2 and MaZEP is anticipated to highlight the difference in artificially induced and natural parthenocarpy. By exploring the PPI of validated genes from the network, we postulated a putative pathway that bring insights into the significance of cytokinin mediated CLAVATA(CLV)–WUSHEL(WUS) signaling pathway in addition to gibberellin mediated auxin signaling in parthenocarpy. Our analysis is the first attempt to identify candidate genes and to hypothesize a putative mechanism that bridges the gaps in understanding natural parthenocarpy through PPI network.
format	article
author	Suthanthiram Backiyarani Rajendran Sasikala Simeon Sharmiladevi Subbaraya Uma
author_facet	Suthanthiram Backiyarani Rajendran Sasikala Simeon Sharmiladevi Subbaraya Uma
author_sort	Suthanthiram Backiyarani
title	Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network
title_short	Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network
title_full	Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network
title_fullStr	Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network
title_full_unstemmed	Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network
title_sort	decoding the molecular mechanism of parthenocarpy in musa spp. through protein–protein interaction network
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4464a55325dd4f688833910e8738a14a
work_keys_str_mv	AT suthanthirambackiyarani decodingthemolecularmechanismofparthenocarpyinmusasppthroughproteinproteininteractionnetwork AT rajendransasikala decodingthemolecularmechanismofparthenocarpyinmusasppthroughproteinproteininteractionnetwork AT simeonsharmiladevi decodingthemolecularmechanismofparthenocarpyinmusasppthroughproteinproteininteractionnetwork AT subbarayauma decodingthemolecularmechanismofparthenocarpyinmusasppthroughproteinproteininteractionnetwork
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Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein–protein interaction network

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