Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.

Croton urucurana Baill. is a native Brazilian tree, popularly known as “sangra-d’água” or “sangue-de-dragão,” based on the red resinous sap of the trunk. Its use has been transmitted through generations based on popular tradition that attributes analgesic, anti-inflammatory, and cardioprotective pro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Priscila Megda João Job Zago, Gustavo Ratti da Silva, Eduarda Carolina Amaral, Lorena Neris Barboza, Fernanda de Abreu Braga, Bethânia Rosa Lorençone, Aline Aparecida Macedo Marques, Karyne Garcia Tafarelo Moreno, Patrícia Regina Terço Leite, Alan de Almeida Veiga, Lauro Mera de Souza, Roosevelt Isaias Carvalho Souza, Ariany Carvalho dos Santos, João Tadeu Ribeiro-Paes, Arquimedes Gasparotto Junior, Francislaine Aparecida dos Reis Lívero
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/4464bef940d342628917fd04c1c43cb4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4464bef940d342628917fd04c1c43cb4
record_format	dspace
spelling	oai:doaj.org-article:4464bef940d342628917fd04c1c43cb42021-11-29T00:55:26ZMultiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.1741-428810.1155/2021/6580458https://doaj.org/article/4464bef940d342628917fd04c1c43cb42021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6580458https://doaj.org/toc/1741-4288Croton urucurana Baill. is a native Brazilian tree, popularly known as “sangra-d’água” or “sangue-de-dragão,” based on the red resinous sap of the trunk. Its use has been transmitted through generations based on popular tradition that attributes analgesic, anti-inflammatory, and cardioprotective properties to the tree. However, its cardioprotective effects have not yet been scientifically investigated. Thus, the present study investigated the pharmacological response to an ethanol-soluble fraction from the leaves of C. urucurana in Wistar rats exposed to smoking and dyslipidemia, two important cardiovascular risk factors. The extract was evaluated by high-performance liquid chromatography. Wistar rats received a 0.5% cholesterol-enriched diet and were exposed to cigarette smoke (9 cigarettes/day for 10 weeks). During the last 5 weeks, the animals were orally treated with vehicle (negative control group), C. urucurana extract (30, 100, and 300 mg/kg), or simvastatin (2.5 mg/kg) + enalapril (15 mg/kg). One group of rats that was not exposed to these risk factors was also evaluated (basal group). Electrocardiograms and systolic, diastolic, and mean blood pressure were measured. Blood was collected to measure total cholesterol, triglycerides, urea, and creatinine. The heart and kidneys were collected and processed for oxidative status and histopathological evaluation. The phytochemical analysis revealed different classes of flavonoids and condensed tannins. The model induced dyslipidemia and cardiac and renal oxidative stress and increased levels of urea and creatinine in the negative control group. Treatment with the C. urucurana extract (300 mg/kg) and simvastatin + enalapril decreased cholesterol and triglyceride levels. In contrast to simvastatin + enalapril treatment, the C. urucurana extract exerted cardiac and renal antioxidant effects. No alterations of electrocardiograms, blood pressure, or histopathology were observed between groups. These findings indicate that C. urucurana exerts lipid-lowering, renal, and cardioprotective effects against oxidative stress in a preclinical model of multiple risk factors for heart disease.Priscila Megda João Job ZagoGustavo Ratti da SilvaEduarda Carolina AmaralLorena Neris BarbozaFernanda de Abreu BragaBethânia Rosa LorençoneAline Aparecida Macedo MarquesKaryne Garcia Tafarelo MorenoPatrícia Regina Terço LeiteAlan de Almeida VeigaLauro Mera de SouzaRoosevelt Isaias Carvalho SouzaAriany Carvalho dos SantosJoão Tadeu Ribeiro-PaesArquimedes Gasparotto JuniorFrancislaine Aparecida dos Reis LíveroHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Priscila Megda João Job Zago Gustavo Ratti da Silva Eduarda Carolina Amaral Lorena Neris Barboza Fernanda de Abreu Braga Bethânia Rosa Lorençone Aline Aparecida Macedo Marques Karyne Garcia Tafarelo Moreno Patrícia Regina Terço Leite Alan de Almeida Veiga Lauro Mera de Souza Roosevelt Isaias Carvalho Souza Ariany Carvalho dos Santos João Tadeu Ribeiro-Paes Arquimedes Gasparotto Junior Francislaine Aparecida dos Reis Lívero Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.
description	Croton urucurana Baill. is a native Brazilian tree, popularly known as “sangra-d’água” or “sangue-de-dragão,” based on the red resinous sap of the trunk. Its use has been transmitted through generations based on popular tradition that attributes analgesic, anti-inflammatory, and cardioprotective properties to the tree. However, its cardioprotective effects have not yet been scientifically investigated. Thus, the present study investigated the pharmacological response to an ethanol-soluble fraction from the leaves of C. urucurana in Wistar rats exposed to smoking and dyslipidemia, two important cardiovascular risk factors. The extract was evaluated by high-performance liquid chromatography. Wistar rats received a 0.5% cholesterol-enriched diet and were exposed to cigarette smoke (9 cigarettes/day for 10 weeks). During the last 5 weeks, the animals were orally treated with vehicle (negative control group), C. urucurana extract (30, 100, and 300 mg/kg), or simvastatin (2.5 mg/kg) + enalapril (15 mg/kg). One group of rats that was not exposed to these risk factors was also evaluated (basal group). Electrocardiograms and systolic, diastolic, and mean blood pressure were measured. Blood was collected to measure total cholesterol, triglycerides, urea, and creatinine. The heart and kidneys were collected and processed for oxidative status and histopathological evaluation. The phytochemical analysis revealed different classes of flavonoids and condensed tannins. The model induced dyslipidemia and cardiac and renal oxidative stress and increased levels of urea and creatinine in the negative control group. Treatment with the C. urucurana extract (300 mg/kg) and simvastatin + enalapril decreased cholesterol and triglyceride levels. In contrast to simvastatin + enalapril treatment, the C. urucurana extract exerted cardiac and renal antioxidant effects. No alterations of electrocardiograms, blood pressure, or histopathology were observed between groups. These findings indicate that C. urucurana exerts lipid-lowering, renal, and cardioprotective effects against oxidative stress in a preclinical model of multiple risk factors for heart disease.
format	article
author	Priscila Megda João Job Zago Gustavo Ratti da Silva Eduarda Carolina Amaral Lorena Neris Barboza Fernanda de Abreu Braga Bethânia Rosa Lorençone Aline Aparecida Macedo Marques Karyne Garcia Tafarelo Moreno Patrícia Regina Terço Leite Alan de Almeida Veiga Lauro Mera de Souza Roosevelt Isaias Carvalho Souza Ariany Carvalho dos Santos João Tadeu Ribeiro-Paes Arquimedes Gasparotto Junior Francislaine Aparecida dos Reis Lívero
author_facet	Priscila Megda João Job Zago Gustavo Ratti da Silva Eduarda Carolina Amaral Lorena Neris Barboza Fernanda de Abreu Braga Bethânia Rosa Lorençone Aline Aparecida Macedo Marques Karyne Garcia Tafarelo Moreno Patrícia Regina Terço Leite Alan de Almeida Veiga Lauro Mera de Souza Roosevelt Isaias Carvalho Souza Ariany Carvalho dos Santos João Tadeu Ribeiro-Paes Arquimedes Gasparotto Junior Francislaine Aparecida dos Reis Lívero
author_sort	Priscila Megda João Job Zago
title	Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.
title_short	Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.
title_full	Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.
title_fullStr	Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.
title_full_unstemmed	Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.
title_sort	multiple risk factors for heart disease: a challenge to the ethnopharmacological use of croton urucurana baill.
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/4464bef940d342628917fd04c1c43cb4
work_keys_str_mv	AT priscilamegdajoaojobzago multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT gustavorattidasilva multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT eduardacarolinaamaral multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT lorenanerisbarboza multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT fernandadeabreubraga multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT bethaniarosalorencone multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT alineaparecidamacedomarques multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT karynegarciatafarelomoreno multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT patriciareginatercoleite multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT alandealmeidaveiga multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT lauromeradesouza multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT rooseveltisaiascarvalhosouza multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT arianycarvalhodossantos multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT joaotadeuribeiropaes multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT arquimedesgasparottojunior multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill AT francislaineaparecidadosreislivero multipleriskfactorsforheartdiseaseachallengetotheethnopharmacologicaluseofcrotonurucuranabaill
_version_	1718407765779546112

Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.

Ejemplares similares