Genetic variants associated with platelet count are predictive of human disease and physiological markers

Genetic variants associated with platelet count are predictive of human disease and physiological markers

Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hype...

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Autores principales: Evgenia Mikaelsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gisli Halldorsson, Jon K. Sigurdsson, Sigrun H. Lund, Vinicius Tragante, Pall Melsted, Solvi Rognvaldsson, Kristjan Norland, Anna Helgadottir, Magnus K. Magnusson, Gunnar B. Ragnarsson, Sigurdur Y. Kristinsson, Sigrun Reykdal, Brynjar Vidarsson, Ingibjorg J. Gudmundsdottir, Isleifur Olafsson, Pall T. Onundarson, Olof Sigurdardottir, Emil L. Sigurdsson, Gerdur Grondal, Arni J. Geirsson, Gudmundur Geirsson, Julius Gudmundsson, Hilma Holm, Saedis Saevarsdottir, Ingileif Jonsdottir, Gudmundur Thorgeirsson, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Kari Stefansson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/446745dde7124b9185d8624ab82cb8ce
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spelling oai:doaj.org-article:446745dde7124b9185d8624ab82cb8ce2021-12-02T17:37:23ZGenetic variants associated with platelet count are predictive of human disease and physiological markers10.1038/s42003-021-02642-92399-3642https://doaj.org/article/446745dde7124b9185d8624ab82cb8ce2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02642-9https://doaj.org/toc/2399-3642Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.Evgenia MikaelsdottirGudmar ThorleifssonLilja StefansdottirGisli HalldorssonJon K. SigurdssonSigrun H. LundVinicius TragantePall MelstedSolvi RognvaldssonKristjan NorlandAnna HelgadottirMagnus K. MagnussonGunnar B. RagnarssonSigurdur Y. KristinssonSigrun ReykdalBrynjar VidarssonIngibjorg J. GudmundsdottirIsleifur OlafssonPall T. OnundarsonOlof SigurdardottirEmil L. SigurdssonGerdur GrondalArni J. GeirssonGudmundur GeirssonJulius GudmundssonHilma HolmSaedis SaevarsdottirIngileif JonsdottirGudmundur ThorgeirssonDaniel F. GudbjartssonUnnur ThorsteinsdottirThorunn RafnarKari StefanssonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Evgenia Mikaelsdottir
Gudmar Thorleifsson
Lilja Stefansdottir
Gisli Halldorsson
Jon K. Sigurdsson
Sigrun H. Lund
Vinicius Tragante
Pall Melsted
Solvi Rognvaldsson
Kristjan Norland
Anna Helgadottir
Magnus K. Magnusson
Gunnar B. Ragnarsson
Sigurdur Y. Kristinsson
Sigrun Reykdal
Brynjar Vidarsson
Ingibjorg J. Gudmundsdottir
Isleifur Olafsson
Pall T. Onundarson
Olof Sigurdardottir
Emil L. Sigurdsson
Gerdur Grondal
Arni J. Geirsson
Gudmundur Geirsson
Julius Gudmundsson
Hilma Holm
Saedis Saevarsdottir
Ingileif Jonsdottir
Gudmundur Thorgeirsson
Daniel F. Gudbjartsson
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson
Genetic variants associated with platelet count are predictive of human disease and physiological markers
description Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.
format article
author Evgenia Mikaelsdottir
Gudmar Thorleifsson
Lilja Stefansdottir
Gisli Halldorsson
Jon K. Sigurdsson
Sigrun H. Lund
Vinicius Tragante
Pall Melsted
Solvi Rognvaldsson
Kristjan Norland
Anna Helgadottir
Magnus K. Magnusson
Gunnar B. Ragnarsson
Sigurdur Y. Kristinsson
Sigrun Reykdal
Brynjar Vidarsson
Ingibjorg J. Gudmundsdottir
Isleifur Olafsson
Pall T. Onundarson
Olof Sigurdardottir
Emil L. Sigurdsson
Gerdur Grondal
Arni J. Geirsson
Gudmundur Geirsson
Julius Gudmundsson
Hilma Holm
Saedis Saevarsdottir
Ingileif Jonsdottir
Gudmundur Thorgeirsson
Daniel F. Gudbjartsson
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson
author_facet Evgenia Mikaelsdottir
Gudmar Thorleifsson
Lilja Stefansdottir
Gisli Halldorsson
Jon K. Sigurdsson
Sigrun H. Lund
Vinicius Tragante
Pall Melsted
Solvi Rognvaldsson
Kristjan Norland
Anna Helgadottir
Magnus K. Magnusson
Gunnar B. Ragnarsson
Sigurdur Y. Kristinsson
Sigrun Reykdal
Brynjar Vidarsson
Ingibjorg J. Gudmundsdottir
Isleifur Olafsson
Pall T. Onundarson
Olof Sigurdardottir
Emil L. Sigurdsson
Gerdur Grondal
Arni J. Geirsson
Gudmundur Geirsson
Julius Gudmundsson
Hilma Holm
Saedis Saevarsdottir
Ingileif Jonsdottir
Gudmundur Thorgeirsson
Daniel F. Gudbjartsson
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson
author_sort Evgenia Mikaelsdottir
title Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_short Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_full Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_fullStr Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_full_unstemmed Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_sort genetic variants associated with platelet count are predictive of human disease and physiological markers
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/446745dde7124b9185d8624ab82cb8ce
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