Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward...

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Autores principales:	Anna Maria Corsale, Marta Di Simone, Elena Lo Presti, Carmela Picone, Francesco Dieli, Serena Meraviglia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumoral metabolism γδ T cells tumor microenvironment Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4469deecc0b64bfbbebec2ea24c8ee99
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spelling	oai:doaj.org-article:4469deecc0b64bfbbebec2ea24c8ee992021-11-25T17:08:36ZMetabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?10.3390/cells101128962073-4409https://doaj.org/article/4469deecc0b64bfbbebec2ea24c8ee992021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2896https://doaj.org/toc/2073-4409The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating their effector functions by in vitro and in vivo approaches. γδ T cells, thanks to their unique features, are themselves a valid alternative to overcome the limits associated with the use of conventional T cells, such as major histocompatibility complex (MHC) restriction, costimulatory signal and specific tumor-associated antigen recognition. Lipids, amino acids, hypoxia, prostaglandins and other metabolic changes inside the tumor microenvironment could reduce the efficacy of this important immune population and polarize γδ T cells toward IL17 producing cells that play a pro tumoral role. A deeper knowledge of this phenomenon could be helpful to formulate new immunotherapeutic approaches that target tumor metabolisms.Anna Maria CorsaleMarta Di SimoneElena Lo PrestiCarmela PiconeFrancesco DieliSerena MeravigliaMDPI AGarticletumoral metabolismγδ T cellstumor microenvironmentBiology (General)QH301-705.5ENCells, Vol 10, Iss 2896, p 2896 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumoral metabolism γδ T cells tumor microenvironment Biology (General) QH301-705.5
spellingShingle	tumoral metabolism γδ T cells tumor microenvironment Biology (General) QH301-705.5 Anna Maria Corsale Marta Di Simone Elena Lo Presti Carmela Picone Francesco Dieli Serena Meraviglia Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
description	The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating their effector functions by in vitro and in vivo approaches. γδ T cells, thanks to their unique features, are themselves a valid alternative to overcome the limits associated with the use of conventional T cells, such as major histocompatibility complex (MHC) restriction, costimulatory signal and specific tumor-associated antigen recognition. Lipids, amino acids, hypoxia, prostaglandins and other metabolic changes inside the tumor microenvironment could reduce the efficacy of this important immune population and polarize γδ T cells toward IL17 producing cells that play a pro tumoral role. A deeper knowledge of this phenomenon could be helpful to formulate new immunotherapeutic approaches that target tumor metabolisms.
format	article
author	Anna Maria Corsale Marta Di Simone Elena Lo Presti Carmela Picone Francesco Dieli Serena Meraviglia
author_facet	Anna Maria Corsale Marta Di Simone Elena Lo Presti Carmela Picone Francesco Dieli Serena Meraviglia
author_sort	Anna Maria Corsale
title	Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
title_short	Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
title_full	Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
title_fullStr	Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
title_full_unstemmed	Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
title_sort	metabolic changes in tumor microenvironment: how could they affect γδ t cells functions?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4469deecc0b64bfbbebec2ea24c8ee99
work_keys_str_mv	AT annamariacorsale metabolicchangesintumormicroenvironmenthowcouldtheyaffectgdtcellsfunctions AT martadisimone metabolicchangesintumormicroenvironmenthowcouldtheyaffectgdtcellsfunctions AT elenalopresti metabolicchangesintumormicroenvironmenthowcouldtheyaffectgdtcellsfunctions AT carmelapicone metabolicchangesintumormicroenvironmenthowcouldtheyaffectgdtcellsfunctions AT francescodieli metabolicchangesintumormicroenvironmenthowcouldtheyaffectgdtcellsfunctions AT serenameraviglia metabolicchangesintumormicroenvironmenthowcouldtheyaffectgdtcellsfunctions
_version_	1718412644717690880

Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

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