Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

Abstract Altered composition of gut bacteria and changes to the production of their bioactive metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of multiple sclerosis (MS). However, the immunomodulatory actions of SCFAs and intermediaries in their ability to in...

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Autores principales:	Stephanie Trend, Jonatan Leffler, Anderson P. Jones, Lilian Cha, Shelley Gorman, David A. Brown, Samuel N. Breit, Allan G. Kermode, Martyn A. French, Natalie C. Ward, Prue H. Hart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/446d312c907640fc9a1032b9313f271d
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spelling	oai:doaj.org-article:446d312c907640fc9a1032b9313f271d2021-12-02T13:30:12ZAssociations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis10.1038/s41598-021-84881-82045-2322https://doaj.org/article/446d312c907640fc9a1032b9313f271d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84881-8https://doaj.org/toc/2045-2322Abstract Altered composition of gut bacteria and changes to the production of their bioactive metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of multiple sclerosis (MS). However, the immunomodulatory actions of SCFAs and intermediaries in their ability to influence MS pathogenesis are uncertain. In this study, levels of serum SCFAs were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome (CIS; an early form of MS) or MS and compared to healthy controls. There was a small but significant reduction in propionate levels in the serum of patients with CIS or MS compared with healthy controls. The frequencies of circulating T follicular regulatory cells and T follicular helper cells were significantly positively correlated with serum levels of propionate. Levels of butyrate associated positively with frequencies of IL-10-producing B-cells and negatively with frequencies of class-switched memory B-cells. TNF production by polyclonally-activated B-cells correlated negatively with acetate levels. Levels of serum SCFAs associated with changes in circulating immune cells and biomarkers implicated in the development of MS.Stephanie TrendJonatan LefflerAnderson P. JonesLilian ChaShelley GormanDavid A. BrownSamuel N. BreitAllan G. KermodeMartyn A. FrenchNatalie C. WardPrue H. HartNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephanie Trend Jonatan Leffler Anderson P. Jones Lilian Cha Shelley Gorman David A. Brown Samuel N. Breit Allan G. Kermode Martyn A. French Natalie C. Ward Prue H. Hart Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
description	Abstract Altered composition of gut bacteria and changes to the production of their bioactive metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of multiple sclerosis (MS). However, the immunomodulatory actions of SCFAs and intermediaries in their ability to influence MS pathogenesis are uncertain. In this study, levels of serum SCFAs were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome (CIS; an early form of MS) or MS and compared to healthy controls. There was a small but significant reduction in propionate levels in the serum of patients with CIS or MS compared with healthy controls. The frequencies of circulating T follicular regulatory cells and T follicular helper cells were significantly positively correlated with serum levels of propionate. Levels of butyrate associated positively with frequencies of IL-10-producing B-cells and negatively with frequencies of class-switched memory B-cells. TNF production by polyclonally-activated B-cells correlated negatively with acetate levels. Levels of serum SCFAs associated with changes in circulating immune cells and biomarkers implicated in the development of MS.
format	article
author	Stephanie Trend Jonatan Leffler Anderson P. Jones Lilian Cha Shelley Gorman David A. Brown Samuel N. Breit Allan G. Kermode Martyn A. French Natalie C. Ward Prue H. Hart
author_facet	Stephanie Trend Jonatan Leffler Anderson P. Jones Lilian Cha Shelley Gorman David A. Brown Samuel N. Breit Allan G. Kermode Martyn A. French Natalie C. Ward Prue H. Hart
author_sort	Stephanie Trend
title	Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
title_short	Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
title_full	Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
title_fullStr	Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
title_full_unstemmed	Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
title_sort	associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/446d312c907640fc9a1032b9313f271d
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Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

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