Delivery luteolin with folacin-modified nanoparticle for glioma therapy

Cong Wu, Qian Xu, Xinyue Chen, Jiagang Liu Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of ChinaCorrespondence: Jiagang LiuDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichua...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wu C, Xu Q, Chen X, Liu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Luteolin PEG-PCL glioma folic acid apoptosis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/446dd61f16fb4a43b6a4c78705d1b1ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:446dd61f16fb4a43b6a4c78705d1b1ff
record_format	dspace
spelling	oai:doaj.org-article:446dd61f16fb4a43b6a4c78705d1b1ff2021-12-02T04:45:09ZDelivery luteolin with folacin-modified nanoparticle for glioma therapy1178-2013https://doaj.org/article/446dd61f16fb4a43b6a4c78705d1b1ff2019-09-01T00:00:00Zhttps://www.dovepress.com/delivery-luteolin-with-folacin-modified-nanoparticle-for-glioma-therap-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Cong Wu, Qian Xu, Xinyue Chen, Jiagang Liu Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of ChinaCorrespondence: Jiagang LiuDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of ChinaTel +86 288 542 2136Fax +86 288 550 2796Email jiagang_liu@163.comBackground: Glioblastoma mutliforme is the most common and has the poorest prognosis of any malignant tumor of the central nervous system. Luteolin, the most abundant xanthone extracted from vegetables and medicinal plants, has been shown to have treatment effects in various cancer cell types. Luteolin is however, hydrophobic and has poor biocompatibility, which leads to low bioavailability.Patients and methods: In this study, folic acid modifiedpoly(ethylene glycol)-poly(e-caprolactone) (Fa-PEG-PCL) nano-micelles was used to encapsulate the luteolin, creating luteolin loaded PEG-PCL (Lut/Fa-PEG-PCL) micelles to treat glioma both in vitro and in vivo.Results: When compared with the free luteolin and Lut/MPEG-PCL, Lut/Fa-PEG-PCL induced a significant cell growth inhibition and more apoptosis of GL261 cells both in vitro and in vivo. The safety assessment also showed no obvious side effects were observed in mice which were administrated with free luteolin or Lut/MPEG-PCL and Lut/Fa-PEG-PCL.Conclusion: These results suggested Lut/Fa-PEG-PCL may be used as an excellent intravenously injectable formulation for the treatment and chemoprevention.Keywords: luteolin, PEG-PCL, glioma, folic acid, apoptosisWu CXu QChen XLiu JDove Medical PressarticleLuteolinPEG-PCLgliomafolic acidapoptosis.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7515-7531 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Luteolin PEG-PCL glioma folic acid apoptosis. Medicine (General) R5-920
spellingShingle	Luteolin PEG-PCL glioma folic acid apoptosis. Medicine (General) R5-920 Wu C Xu Q Chen X Liu J Delivery luteolin with folacin-modified nanoparticle for glioma therapy
description	Cong Wu, Qian Xu, Xinyue Chen, Jiagang Liu Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of ChinaCorrespondence: Jiagang LiuDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of ChinaTel +86 288 542 2136Fax +86 288 550 2796Email jiagang_liu@163.comBackground: Glioblastoma mutliforme is the most common and has the poorest prognosis of any malignant tumor of the central nervous system. Luteolin, the most abundant xanthone extracted from vegetables and medicinal plants, has been shown to have treatment effects in various cancer cell types. Luteolin is however, hydrophobic and has poor biocompatibility, which leads to low bioavailability.Patients and methods: In this study, folic acid modifiedpoly(ethylene glycol)-poly(e-caprolactone) (Fa-PEG-PCL) nano-micelles was used to encapsulate the luteolin, creating luteolin loaded PEG-PCL (Lut/Fa-PEG-PCL) micelles to treat glioma both in vitro and in vivo.Results: When compared with the free luteolin and Lut/MPEG-PCL, Lut/Fa-PEG-PCL induced a significant cell growth inhibition and more apoptosis of GL261 cells both in vitro and in vivo. The safety assessment also showed no obvious side effects were observed in mice which were administrated with free luteolin or Lut/MPEG-PCL and Lut/Fa-PEG-PCL.Conclusion: These results suggested Lut/Fa-PEG-PCL may be used as an excellent intravenously injectable formulation for the treatment and chemoprevention.Keywords: luteolin, PEG-PCL, glioma, folic acid, apoptosis
format	article
author	Wu C Xu Q Chen X Liu J
author_facet	Wu C Xu Q Chen X Liu J
author_sort	Wu C
title	Delivery luteolin with folacin-modified nanoparticle for glioma therapy
title_short	Delivery luteolin with folacin-modified nanoparticle for glioma therapy
title_full	Delivery luteolin with folacin-modified nanoparticle for glioma therapy
title_fullStr	Delivery luteolin with folacin-modified nanoparticle for glioma therapy
title_full_unstemmed	Delivery luteolin with folacin-modified nanoparticle for glioma therapy
title_sort	delivery luteolin with folacin-modified nanoparticle for glioma therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/446dd61f16fb4a43b6a4c78705d1b1ff
work_keys_str_mv	AT wuc deliveryluteolinwithfolacinmodifiednanoparticleforgliomatherapy AT xuq deliveryluteolinwithfolacinmodifiednanoparticleforgliomatherapy AT chenx deliveryluteolinwithfolacinmodifiednanoparticleforgliomatherapy AT liuj deliveryluteolinwithfolacinmodifiednanoparticleforgliomatherapy
_version_	1718401080926142464

Delivery luteolin with folacin-modified nanoparticle for glioma therapy

Ejemplares similares