Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrop...
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oai:doaj.org-article:446e3bf180e2420eb69f8ef9d36c72c62021-11-18T07:22:49ZLonger leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.1932-620310.1371/journal.pone.0034292https://doaj.org/article/446e3bf180e2420eb69f8ef9d36c72c62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22506016/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s) = -0.465; p = 0.011), right (r(s) = -0.414; p = 0.025), and total hippocampus volume (r(s) = -0.519; p = 0.004) among APOE ε3/ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3/ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3/ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.Mikael WikgrenThomas KarlssonJohanna LindTherese NilbrinkJohan HultdinKristel SleegersChristine Van BroeckhovenGöran RoosLars-Göran NilssonLars NybergRolf AdolfssonKarl-Fredrik NorrbackPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34292 (2012) |
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Medicine R Science Q Mikael Wikgren Thomas Karlsson Johanna Lind Therese Nilbrink Johan Hultdin Kristel Sleegers Christine Van Broeckhoven Göran Roos Lars-Göran Nilsson Lars Nyberg Rolf Adolfsson Karl-Fredrik Norrback Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. |
description |
Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s) = -0.465; p = 0.011), right (r(s) = -0.414; p = 0.025), and total hippocampus volume (r(s) = -0.519; p = 0.004) among APOE ε3/ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3/ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3/ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain. |
format |
article |
author |
Mikael Wikgren Thomas Karlsson Johanna Lind Therese Nilbrink Johan Hultdin Kristel Sleegers Christine Van Broeckhoven Göran Roos Lars-Göran Nilsson Lars Nyberg Rolf Adolfsson Karl-Fredrik Norrback |
author_facet |
Mikael Wikgren Thomas Karlsson Johanna Lind Therese Nilbrink Johan Hultdin Kristel Sleegers Christine Van Broeckhoven Göran Roos Lars-Göran Nilsson Lars Nyberg Rolf Adolfsson Karl-Fredrik Norrback |
author_sort |
Mikael Wikgren |
title |
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. |
title_short |
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. |
title_full |
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. |
title_fullStr |
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. |
title_full_unstemmed |
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects. |
title_sort |
longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented apoe ε3/ε3 subjects. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doaj.org/article/446e3bf180e2420eb69f8ef9d36c72c6 |
work_keys_str_mv |
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