Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.

Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrop...

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Autores principales: Mikael Wikgren, Thomas Karlsson, Johanna Lind, Therese Nilbrink, Johan Hultdin, Kristel Sleegers, Christine Van Broeckhoven, Göran Roos, Lars-Göran Nilsson, Lars Nyberg, Rolf Adolfsson, Karl-Fredrik Norrback
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Publicado: Public Library of Science (PLoS) 2012
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spelling oai:doaj.org-article:446e3bf180e2420eb69f8ef9d36c72c62021-11-18T07:22:49ZLonger leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.1932-620310.1371/journal.pone.0034292https://doaj.org/article/446e3bf180e2420eb69f8ef9d36c72c62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22506016/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s) = -0.465; p = 0.011), right (r(s) = -0.414; p = 0.025), and total hippocampus volume (r(s) = -0.519; p = 0.004) among APOE ε3/ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3/ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3/ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.Mikael WikgrenThomas KarlssonJohanna LindTherese NilbrinkJohan HultdinKristel SleegersChristine Van BroeckhovenGöran RoosLars-Göran NilssonLars NybergRolf AdolfssonKarl-Fredrik NorrbackPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34292 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mikael Wikgren
Thomas Karlsson
Johanna Lind
Therese Nilbrink
Johan Hultdin
Kristel Sleegers
Christine Van Broeckhoven
Göran Roos
Lars-Göran Nilsson
Lars Nyberg
Rolf Adolfsson
Karl-Fredrik Norrback
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
description Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s) = -0.465; p = 0.011), right (r(s) = -0.414; p = 0.025), and total hippocampus volume (r(s) = -0.519; p = 0.004) among APOE ε3/ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3/ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3/ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.
format article
author Mikael Wikgren
Thomas Karlsson
Johanna Lind
Therese Nilbrink
Johan Hultdin
Kristel Sleegers
Christine Van Broeckhoven
Göran Roos
Lars-Göran Nilsson
Lars Nyberg
Rolf Adolfsson
Karl-Fredrik Norrback
author_facet Mikael Wikgren
Thomas Karlsson
Johanna Lind
Therese Nilbrink
Johan Hultdin
Kristel Sleegers
Christine Van Broeckhoven
Göran Roos
Lars-Göran Nilsson
Lars Nyberg
Rolf Adolfsson
Karl-Fredrik Norrback
author_sort Mikael Wikgren
title Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
title_short Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
title_full Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
title_fullStr Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
title_full_unstemmed Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects.
title_sort longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented apoe ε3/ε3 subjects.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/446e3bf180e2420eb69f8ef9d36c72c6
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