Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients

Shuang Liang,1 Wanxia Niu,1 Helei Wang,2 Lixia Yang2 1Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People...

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Autores principales:	Liang S, Niu W, Wang H, Yang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lipid layer thickness diabetes ocular surface parameters Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/446f5b386c274c96804a030d32e338f8
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spelling	oai:doaj.org-article:446f5b386c274c96804a030d32e338f82021-12-02T18:52:10ZAlterations of Ocular Surface Parameters in Type 2 Diabetic Patients1178-7007https://doaj.org/article/446f5b386c274c96804a030d32e338f82021-08-01T00:00:00Zhttps://www.dovepress.com/alterations-of-ocular-surface-parameters-in-type-2-diabetic-patients-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Shuang Liang,1 Wanxia Niu,1 Helei Wang,2 Lixia Yang2 1Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaCorrespondence: Lixia YangDepartment of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Beiyuan Main Street, Jinan, 250021, People’s Republic of ChinaTel +86 17660083151Email 15153169515@163.comObjective: The purpose of the study was to evaluate the changes in the ocular surface parameters of type 2 diabetic patients.Methods: This study is a cross-sectional observational study. It included 76 eyes of 38 patients with type 2 diabetes and 183 eyes of 92 non-diabetic controls. The diabetic subjects were divided into two groups based on diabetic duration. Ocular surface parameters were assessed for all participants.Results: The diabetic group had a significantly thinner lipid layer thickness (LLT) (p = 0.008) than non-diabetic controls. LLT in the subgroup with diabetic duration ≥ 10 years was significantly thinner than that in the subgroup with diabetic duration < 10 years (p = 0.006). Multivariate linear regression analysis showed that LLT was associated with the duration of diabetes (β = − 1.497, p = 0.009) and Schirmer I test (SIT) score (β = 0.852, p = 0.04) in diabetic. Diabetic duration was significantly negatively associated with LLT (β = − 0.062, p = 0.004) and significantly positively associated with ocular surface disease index (OSDI) (β = 0.087, p = 0.039).Conclusion: Diabetic patients exhibit significantly reduced LLT and this trend becomes more pronounced with increased duration of diabetes.Keywords: lipid layer thickness, diabetes, ocular surface parametersLiang SNiu WWang HYang LDove Medical Pressarticlelipid layer thicknessdiabetesocular surface parametersSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3787-3793 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid layer thickness diabetes ocular surface parameters Specialties of internal medicine RC581-951
spellingShingle	lipid layer thickness diabetes ocular surface parameters Specialties of internal medicine RC581-951 Liang S Niu W Wang H Yang L Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients
description	Shuang Liang,1 Wanxia Niu,1 Helei Wang,2 Lixia Yang2 1Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaCorrespondence: Lixia YangDepartment of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Beiyuan Main Street, Jinan, 250021, People’s Republic of ChinaTel +86 17660083151Email 15153169515@163.comObjective: The purpose of the study was to evaluate the changes in the ocular surface parameters of type 2 diabetic patients.Methods: This study is a cross-sectional observational study. It included 76 eyes of 38 patients with type 2 diabetes and 183 eyes of 92 non-diabetic controls. The diabetic subjects were divided into two groups based on diabetic duration. Ocular surface parameters were assessed for all participants.Results: The diabetic group had a significantly thinner lipid layer thickness (LLT) (p = 0.008) than non-diabetic controls. LLT in the subgroup with diabetic duration ≥ 10 years was significantly thinner than that in the subgroup with diabetic duration < 10 years (p = 0.006). Multivariate linear regression analysis showed that LLT was associated with the duration of diabetes (β = − 1.497, p = 0.009) and Schirmer I test (SIT) score (β = 0.852, p = 0.04) in diabetic. Diabetic duration was significantly negatively associated with LLT (β = − 0.062, p = 0.004) and significantly positively associated with ocular surface disease index (OSDI) (β = 0.087, p = 0.039).Conclusion: Diabetic patients exhibit significantly reduced LLT and this trend becomes more pronounced with increased duration of diabetes.Keywords: lipid layer thickness, diabetes, ocular surface parameters
format	article
author	Liang S Niu W Wang H Yang L
author_facet	Liang S Niu W Wang H Yang L
author_sort	Liang S
title	Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients
title_short	Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients
title_full	Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients
title_fullStr	Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients
title_full_unstemmed	Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients
title_sort	alterations of ocular surface parameters in type 2 diabetic patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/446f5b386c274c96804a030d32e338f8
work_keys_str_mv	AT liangs alterationsofocularsurfaceparametersintype2diabeticpatients AT niuw alterationsofocularsurfaceparametersintype2diabeticpatients AT wangh alterationsofocularsurfaceparametersintype2diabeticpatients AT yangl alterationsofocularsurfaceparametersintype2diabeticpatients
_version_	1718377381092130816

Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients

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