Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy

Introduction: Laparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C...

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Autores principales:	Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Sho Tanaka, Naoyuki Kawagoe, Taiki Nabekura, Takashi Oshiro, Daiji Nagayama, Ichiro Tatsuno, Atsuhito Saiki
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	obesity laparoscopic sleeve gastrectomy high-density lipoprotein cholesterol triglyceride lipoprotein lipase Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/447374fe802c4543b6f3ebeda76ee521
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spelling	oai:doaj.org-article:447374fe802c4543b6f3ebeda76ee5212021-11-04T14:40:31ZDecreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy1662-40251662-403310.1159/000519410https://doaj.org/article/447374fe802c4543b6f3ebeda76ee5212021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519410https://doaj.org/toc/1662-4025https://doaj.org/toc/1662-4033Introduction: Laparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG. Methods: We retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG. Results: A significant decrease was observed in the patients’ BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG. Discussion/Conclusion: These results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG.Masahiro OhiraYasuhiro WatanabeTakashi YamaguchiHiroki OndaShuhei YamaokaKazuki AbeShoko NakamuraSho TanakaNaoyuki KawagoeTaiki NabekuraTakashi OshiroDaiji NagayamaIchiro TatsunoAtsuhito SaikiKarger Publishersarticleobesitylaparoscopic sleeve gastrectomyhigh-density lipoprotein cholesteroltriglyceridelipoprotein lipaseNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENObesity Facts, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity laparoscopic sleeve gastrectomy high-density lipoprotein cholesterol triglyceride lipoprotein lipase Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	obesity laparoscopic sleeve gastrectomy high-density lipoprotein cholesterol triglyceride lipoprotein lipase Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Sho Tanaka Naoyuki Kawagoe Taiki Nabekura Takashi Oshiro Daiji Nagayama Ichiro Tatsuno Atsuhito Saiki Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
description	Introduction: Laparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG. Methods: We retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG. Results: A significant decrease was observed in the patients’ BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG. Discussion/Conclusion: These results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG.
format	article
author	Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Sho Tanaka Naoyuki Kawagoe Taiki Nabekura Takashi Oshiro Daiji Nagayama Ichiro Tatsuno Atsuhito Saiki
author_facet	Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Sho Tanaka Naoyuki Kawagoe Taiki Nabekura Takashi Oshiro Daiji Nagayama Ichiro Tatsuno Atsuhito Saiki
author_sort	Masahiro Ohira
title	Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
title_short	Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
title_full	Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
title_fullStr	Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
title_full_unstemmed	Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
title_sort	decreased triglyceride and increased serum lipoprotein lipase levels are correlated to increased high-density lipoprotein-cholesterol levels after laparoscopic sleeve gastrectomy
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/447374fe802c4543b6f3ebeda76ee521
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Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy

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