A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels

An excessive inflammatory response to SARS-CoV-2 is thought to be a major cause of disease severity and mortality in patients with COVID-19. Longitudinal analysis of cytokine release can expand our understanding of the initial stages of disease development and help to identify early markers serving...

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Autores principales:	Denis A. Kleymenov, Evgeniia N. Bykonia, Liubov I. Popova, Elena P. Mazunina, Vladimir A. Gushchin, Liudmila V. Kolobukhina, Olga A. Burgasova, Irina S. Kruzhkova, Nadezhda A. Kuznetsova, Elena V. Shidlovskaya, Elizaveta V. Divisenko, Andrei A. Pochtovyi, Valeria V. Bacalin, Svetlana V. Smetanina, Artem P. Tkachuk, Denis Y. Logunov, Alexander L. Gintsburg
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 COVID-19 cytokines severity predictors hyperinflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/447677bb15474989b59f770f789a736f
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spelling	oai:doaj.org-article:447677bb15474989b59f770f789a736f2021-11-09T06:50:57ZA Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels1664-322410.3389/fimmu.2021.771609https://doaj.org/article/447677bb15474989b59f770f789a736f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.771609/fullhttps://doaj.org/toc/1664-3224An excessive inflammatory response to SARS-CoV-2 is thought to be a major cause of disease severity and mortality in patients with COVID-19. Longitudinal analysis of cytokine release can expand our understanding of the initial stages of disease development and help to identify early markers serving as predictors of disease severity. In this study, we performed a comprehensive analysis of 46 cytokines (including chemokines and growth factors) in the peripheral blood of a large cohort of COVID-19 patients (n=444). The patients were classified into five severity groups. Longitudinal analysis of all patients revealed two groups of cytokines, characterizing the “early” and “late” stages of the disease course and the switch between type 1 and type 2 immunity. We found significantly increased levels of cytokines associated with different severities of COVID-19, and levels of some cytokines were significantly higher during the first three days from symptom onset (DfSO) in patients who eventually required intensive care unit (ICU) therapy. Additionally, we identified nine cytokines, TNF-α, IL-10, MIG, IL-6, IP-10, M-CSF, G-CSF, GM-CSF, and IFN-α2, that can be used as good predictors of ICU requirement at 4-6 DfSO.Denis A. KleymenovEvgeniia N. BykoniaLiubov I. PopovaElena P. MazuninaVladimir A. GushchinVladimir A. GushchinLiudmila V. KolobukhinaLiudmila V. KolobukhinaOlga A. BurgasovaOlga A. BurgasovaOlga A. BurgasovaIrina S. KruzhkovaNadezhda A. KuznetsovaElena V. ShidlovskayaElizaveta V. DivisenkoAndrei A. PochtovyiAndrei A. PochtovyiValeria V. BacalinValeria V. BacalinSvetlana V. SmetaninaArtem P. TkachukDenis Y. LogunovAlexander L. GintsburgAlexander L. GintsburgFrontiers Media S.A.articleSARS-CoV-2COVID-19cytokinesseverity predictorshyperinflammationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 cytokines severity predictors hyperinflammation Immunologic diseases. Allergy RC581-607
spellingShingle	SARS-CoV-2 COVID-19 cytokines severity predictors hyperinflammation Immunologic diseases. Allergy RC581-607 Denis A. Kleymenov Evgeniia N. Bykonia Liubov I. Popova Elena P. Mazunina Vladimir A. Gushchin Vladimir A. Gushchin Liudmila V. Kolobukhina Liudmila V. Kolobukhina Olga A. Burgasova Olga A. Burgasova Olga A. Burgasova Irina S. Kruzhkova Nadezhda A. Kuznetsova Elena V. Shidlovskaya Elizaveta V. Divisenko Andrei A. Pochtovyi Andrei A. Pochtovyi Valeria V. Bacalin Valeria V. Bacalin Svetlana V. Smetanina Artem P. Tkachuk Denis Y. Logunov Alexander L. Gintsburg Alexander L. Gintsburg A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
description	An excessive inflammatory response to SARS-CoV-2 is thought to be a major cause of disease severity and mortality in patients with COVID-19. Longitudinal analysis of cytokine release can expand our understanding of the initial stages of disease development and help to identify early markers serving as predictors of disease severity. In this study, we performed a comprehensive analysis of 46 cytokines (including chemokines and growth factors) in the peripheral blood of a large cohort of COVID-19 patients (n=444). The patients were classified into five severity groups. Longitudinal analysis of all patients revealed two groups of cytokines, characterizing the “early” and “late” stages of the disease course and the switch between type 1 and type 2 immunity. We found significantly increased levels of cytokines associated with different severities of COVID-19, and levels of some cytokines were significantly higher during the first three days from symptom onset (DfSO) in patients who eventually required intensive care unit (ICU) therapy. Additionally, we identified nine cytokines, TNF-α, IL-10, MIG, IL-6, IP-10, M-CSF, G-CSF, GM-CSF, and IFN-α2, that can be used as good predictors of ICU requirement at 4-6 DfSO.
format	article
author	Denis A. Kleymenov Evgeniia N. Bykonia Liubov I. Popova Elena P. Mazunina Vladimir A. Gushchin Vladimir A. Gushchin Liudmila V. Kolobukhina Liudmila V. Kolobukhina Olga A. Burgasova Olga A. Burgasova Olga A. Burgasova Irina S. Kruzhkova Nadezhda A. Kuznetsova Elena V. Shidlovskaya Elizaveta V. Divisenko Andrei A. Pochtovyi Andrei A. Pochtovyi Valeria V. Bacalin Valeria V. Bacalin Svetlana V. Smetanina Artem P. Tkachuk Denis Y. Logunov Alexander L. Gintsburg Alexander L. Gintsburg
author_facet	Denis A. Kleymenov Evgeniia N. Bykonia Liubov I. Popova Elena P. Mazunina Vladimir A. Gushchin Vladimir A. Gushchin Liudmila V. Kolobukhina Liudmila V. Kolobukhina Olga A. Burgasova Olga A. Burgasova Olga A. Burgasova Irina S. Kruzhkova Nadezhda A. Kuznetsova Elena V. Shidlovskaya Elizaveta V. Divisenko Andrei A. Pochtovyi Andrei A. Pochtovyi Valeria V. Bacalin Valeria V. Bacalin Svetlana V. Smetanina Artem P. Tkachuk Denis Y. Logunov Alexander L. Gintsburg Alexander L. Gintsburg
author_sort	Denis A. Kleymenov
title	A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
title_short	A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
title_full	A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
title_fullStr	A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
title_full_unstemmed	A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
title_sort	deep look into covid-19 severity through dynamic changes in blood cytokine levels
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/447677bb15474989b59f770f789a736f
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A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels

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