Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.
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Nature Portfolio
2021
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oai:doaj.org-article:4477922c33134d2989690669cbc5e8c02021-12-02T14:29:01ZCancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition10.1038/s41467-021-22643-w2041-1723https://doaj.org/article/4477922c33134d2989690669cbc5e8c02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22643-whttps://doaj.org/toc/2041-1723Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.Federica VerginelliAlberto PisacaneGennaro GambardellaAntonio D’AmbrosioErmes CandielloMarco FerrioMara PaneroLaura CasorzoSilvia BenvenutiEliano CascardiRebecca SenettaElena GeunaAndrea BallabioFilippo MontemurroAnna SapinoPaolo M. ComoglioCarla BoccaccioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Federica Verginelli Alberto Pisacane Gennaro Gambardella Antonio D’Ambrosio Ermes Candiello Marco Ferrio Mara Panero Laura Casorzo Silvia Benvenuti Eliano Cascardi Rebecca Senetta Elena Geuna Andrea Ballabio Filippo Montemurro Anna Sapino Paolo M. Comoglio Carla Boccaccio Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition |
| description |
Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features. |
| format |
article |
| author |
Federica Verginelli Alberto Pisacane Gennaro Gambardella Antonio D’Ambrosio Ermes Candiello Marco Ferrio Mara Panero Laura Casorzo Silvia Benvenuti Eliano Cascardi Rebecca Senetta Elena Geuna Andrea Ballabio Filippo Montemurro Anna Sapino Paolo M. Comoglio Carla Boccaccio |
| author_facet |
Federica Verginelli Alberto Pisacane Gennaro Gambardella Antonio D’Ambrosio Ermes Candiello Marco Ferrio Mara Panero Laura Casorzo Silvia Benvenuti Eliano Cascardi Rebecca Senetta Elena Geuna Andrea Ballabio Filippo Montemurro Anna Sapino Paolo M. Comoglio Carla Boccaccio |
| author_sort |
Federica Verginelli |
| title |
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition |
| title_short |
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition |
| title_full |
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition |
| title_fullStr |
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition |
| title_full_unstemmed |
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition |
| title_sort |
cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to mek inhibition |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4477922c33134d2989690669cbc5e8c0 |
| work_keys_str_mv |
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| _version_ |
1718391248058843136 |