Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review

Larissa T Alvarim,1,3,* Leopoldo P Nucci,2,* Javier B Mamani,1 Luciana C Marti,1 Marina F Aguiar,1,2 Helio R Silva,1,3 Gisele S Silva,1 Mariana P Nucci-da-Silva,4 Elaine A DelBel,5,6 Lionel F Gamarra1–31Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Universidade Federa...

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Autores principales:	Alvarim LT, Nucci LP, Mamani JB, Marti LC, Aguiar MF, Silva HR, Silva GS, Nucci-da-Silva MP, DelBel EA, Gamarra LF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/447d2434ae2e43f29e8d9c9c40014f81
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spelling	oai:doaj.org-article:447d2434ae2e43f29e8d9c9c40014f812021-12-02T02:56:02ZTherapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review1178-2013https://doaj.org/article/447d2434ae2e43f29e8d9c9c40014f812014-08-01T00:00:00Zhttp://www.dovepress.com/therapeutics-with-spion-labeled-stem-cells-for-the-main-diseases-relat-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Larissa T Alvarim,1,3,* Leopoldo P Nucci,2,* Javier B Mamani,1 Luciana C Marti,1 Marina F Aguiar,1,2 Helio R Silva,1,3 Gisele S Silva,1 Mariana P Nucci-da-Silva,4 Elaine A DelBel,5,6 Lionel F Gamarra1–31Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil; 3Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil; 4Departamento de Radiologia, Hospital das Clínicas, Universidade de São Paulo, Brazil; 5Universidade de São Paulo-Faculdade de Odontologia de Ribeirão Preto, São Paulo, Brazil; 6NAPNA- Núcleo de Apoio a Pesquisa em Neurociências Aplicadas, São Paulo, Brazil*These authors contributed equally to this workAbstract: The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson’s disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain.Keywords: iron oxide, dementia, stem cell, stroke, Parkinson’s disease, sclerosis disease, brain agingAlvarim LTNucci LPMamani JBMarti LCAguiar MFSilva HRSilva GSNucci-da-Silva MPDelBel EAGamarra LFDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3749-3770 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Alvarim LT Nucci LP Mamani JB Marti LC Aguiar MF Silva HR Silva GS Nucci-da-Silva MP DelBel EA Gamarra LF Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
description	Larissa T Alvarim,1,3,* Leopoldo P Nucci,2,* Javier B Mamani,1 Luciana C Marti,1 Marina F Aguiar,1,2 Helio R Silva,1,3 Gisele S Silva,1 Mariana P Nucci-da-Silva,4 Elaine A DelBel,5,6 Lionel F Gamarra1–31Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil; 3Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil; 4Departamento de Radiologia, Hospital das Clínicas, Universidade de São Paulo, Brazil; 5Universidade de São Paulo-Faculdade de Odontologia de Ribeirão Preto, São Paulo, Brazil; 6NAPNA- Núcleo de Apoio a Pesquisa em Neurociências Aplicadas, São Paulo, Brazil*These authors contributed equally to this workAbstract: The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson’s disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain.Keywords: iron oxide, dementia, stem cell, stroke, Parkinson’s disease, sclerosis disease, brain aging
format	article
author	Alvarim LT Nucci LP Mamani JB Marti LC Aguiar MF Silva HR Silva GS Nucci-da-Silva MP DelBel EA Gamarra LF
author_facet	Alvarim LT Nucci LP Mamani JB Marti LC Aguiar MF Silva HR Silva GS Nucci-da-Silva MP DelBel EA Gamarra LF
author_sort	Alvarim LT
title	Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
title_short	Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
title_full	Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
title_fullStr	Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
title_full_unstemmed	Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
title_sort	therapeutics with spion-labeled stem cells for the main diseases related to brain aging: a systematic review
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/447d2434ae2e43f29e8d9c9c40014f81
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Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review

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