A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism

Background To compare the short-term clinical outcomes of ultrasound-guided microwave ablation (MWA) and parathyroidectomy (PTX) for severe secondary hyperparathyroidism(SHPT). Methods In a prospective multi-center study, we compared the outcomes of MWA and PTX for severe SHPT. The outcome measures...

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Autores principales:	Junfeng Zhao, Linxue Qian, Changsheng Teng, Mingan Yu, Fangyi Liu, Yujiang Liu, Xiaoqu Tan, Jianming Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	non-randomized controlled study ultrasound-guided microwave ablation parathyroidectomy secondary hyperparathyroidism Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/447dbd446bee411dac6c3f40fa308058
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spelling	oai:doaj.org-article:447dbd446bee411dac6c3f40fa3080582021-11-04T15:00:41ZA short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism0265-67361464-515710.1080/02656736.2021.1904153https://doaj.org/article/447dbd446bee411dac6c3f40fa3080582021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.1904153https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Background To compare the short-term clinical outcomes of ultrasound-guided microwave ablation (MWA) and parathyroidectomy (PTX) for severe secondary hyperparathyroidism(SHPT). Methods In a prospective multi-center study, we compared the outcomes of MWA and PTX for severe SHPT. The outcome measures were case rate of successful treatment, improvement of clinical symptoms, incidence of complications, and differences in treatment parameters and costs between the two groups. Results A total of 167 eligible patients were included in the study, of which 79 underwent MWA and 88 underwent PTX. There was no significant difference in rate of successful treatment between the MWA and PTX groups (χ2=2.299, p = 0.125). However, the MWA group showed significantly lower range of intact parathyroid hormone (iPTH) decrease than the PTX group (t=−2.352, p = 0.023). Postoperative clinical symptoms improved in both groups, with no significant difference between the two groups (p > 0.05). Postoperative hypocalcemia was significantly more common in the PTX group (p < 0.05). The operative time, incision and postoperative pain of the MWA group were significantly better than those of the PTX group (p < 0.05), while postoperative recurrent laryngeal nerve injury and hematoma showed no significant difference between the two groups (p > 0.05). The cost of MWA was significantly less than PTX (p = 0.000). Conclusions Both MWA and PTX are effective and safe for severe secondary hyperparathyroidism. PTX is more thorough and traumatic, while MWA is minimally invasive and postoperative iPTH is more consistent with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendation.Junfeng ZhaoLinxue QianChangsheng TengMingan YuFangyi LiuYujiang LiuXiaoqu TanJianming LiTaylor & Francis Grouparticlenon-randomized controlled studyultrasound-guidedmicrowave ablationparathyroidectomysecondary hyperparathyroidismMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 1558-1565 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-randomized controlled study ultrasound-guided microwave ablation parathyroidectomy secondary hyperparathyroidism Medical technology R855-855.5
spellingShingle	non-randomized controlled study ultrasound-guided microwave ablation parathyroidectomy secondary hyperparathyroidism Medical technology R855-855.5 Junfeng Zhao Linxue Qian Changsheng Teng Mingan Yu Fangyi Liu Yujiang Liu Xiaoqu Tan Jianming Li A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
description	Background To compare the short-term clinical outcomes of ultrasound-guided microwave ablation (MWA) and parathyroidectomy (PTX) for severe secondary hyperparathyroidism(SHPT). Methods In a prospective multi-center study, we compared the outcomes of MWA and PTX for severe SHPT. The outcome measures were case rate of successful treatment, improvement of clinical symptoms, incidence of complications, and differences in treatment parameters and costs between the two groups. Results A total of 167 eligible patients were included in the study, of which 79 underwent MWA and 88 underwent PTX. There was no significant difference in rate of successful treatment between the MWA and PTX groups (χ2=2.299, p = 0.125). However, the MWA group showed significantly lower range of intact parathyroid hormone (iPTH) decrease than the PTX group (t=−2.352, p = 0.023). Postoperative clinical symptoms improved in both groups, with no significant difference between the two groups (p > 0.05). Postoperative hypocalcemia was significantly more common in the PTX group (p < 0.05). The operative time, incision and postoperative pain of the MWA group were significantly better than those of the PTX group (p < 0.05), while postoperative recurrent laryngeal nerve injury and hematoma showed no significant difference between the two groups (p > 0.05). The cost of MWA was significantly less than PTX (p = 0.000). Conclusions Both MWA and PTX are effective and safe for severe secondary hyperparathyroidism. PTX is more thorough and traumatic, while MWA is minimally invasive and postoperative iPTH is more consistent with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendation.
format	article
author	Junfeng Zhao Linxue Qian Changsheng Teng Mingan Yu Fangyi Liu Yujiang Liu Xiaoqu Tan Jianming Li
author_facet	Junfeng Zhao Linxue Qian Changsheng Teng Mingan Yu Fangyi Liu Yujiang Liu Xiaoqu Tan Jianming Li
author_sort	Junfeng Zhao
title	A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
title_short	A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
title_full	A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
title_fullStr	A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
title_full_unstemmed	A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
title_sort	short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/447dbd446bee411dac6c3f40fa308058
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A short-term non-randomized controlled study of ultrasound-guided microwave ablation and parathyroidectomy for secondary hyperparathyroidism

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