Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds

Abstract Diabetes Mellitus is one of the most worrying issues among illnesses, and its chronic subsequences almost refer to inflammations and infections. The loading and local release of antioxidants to wounds may decrease inflammations. However, the low wettability of PolyPropylene (PP) restricts t...

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Autores principales:	Leila Zahedi, Pedram Ghourchi Beigi, Mojtaba Shafiee, Fatemeh Zare, Hamed Mahdikia, Majid Abdouss, Mohammad-Amin Abdollahifar, Babak Shokri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/447f723ff31b4227815b123639bb59e1
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spelling	oai:doaj.org-article:447f723ff31b4227815b123639bb59e12021-12-02T14:49:43ZDevelopment of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds10.1038/s41598-021-89105-72045-2322https://doaj.org/article/447f723ff31b4227815b123639bb59e12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89105-7https://doaj.org/toc/2045-2322Abstract Diabetes Mellitus is one of the most worrying issues among illnesses, and its chronic subsequences almost refer to inflammations and infections. The loading and local release of antioxidants to wounds may decrease inflammations. However, the low wettability of PolyPropylene (PP) restricts the drug from loading. So, to increase the adhesion of PP for loading an optimum amount of Betaine Hydrochloride (BET), plasma has been applied in two steps of functionalization and polymerization, which has been confirmed with FE-SEM, ATR-FTIR, and EDX. The new chemistry of the surface led to almost 80% of BET loaded. The drug-releasing ratio studied by HPLC approved the presence of a PEG-like layer, which was coated by polymerization of tetraglyme. To evaluate the wound healing potential of the application of PP meshes treated by plasma, 72 Wistar rats were subdivided into four groups. The skin injury site was removed and underwent biomechanical tests, stereological analysis, and RNA extraction. The results showed a significant improvement in the polymerized scaffold containing BET for skin injury. The present study suggests that the use of a modified PP mesh can induce tissue regeneration and accelerate wound healing at the skin injury site.Leila ZahediPedram Ghourchi BeigiMojtaba ShafieeFatemeh ZareHamed MahdikiaMajid AbdoussMohammad-Amin AbdollahifarBabak ShokriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leila Zahedi Pedram Ghourchi Beigi Mojtaba Shafiee Fatemeh Zare Hamed Mahdikia Majid Abdouss Mohammad-Amin Abdollahifar Babak Shokri Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
description	Abstract Diabetes Mellitus is one of the most worrying issues among illnesses, and its chronic subsequences almost refer to inflammations and infections. The loading and local release of antioxidants to wounds may decrease inflammations. However, the low wettability of PolyPropylene (PP) restricts the drug from loading. So, to increase the adhesion of PP for loading an optimum amount of Betaine Hydrochloride (BET), plasma has been applied in two steps of functionalization and polymerization, which has been confirmed with FE-SEM, ATR-FTIR, and EDX. The new chemistry of the surface led to almost 80% of BET loaded. The drug-releasing ratio studied by HPLC approved the presence of a PEG-like layer, which was coated by polymerization of tetraglyme. To evaluate the wound healing potential of the application of PP meshes treated by plasma, 72 Wistar rats were subdivided into four groups. The skin injury site was removed and underwent biomechanical tests, stereological analysis, and RNA extraction. The results showed a significant improvement in the polymerized scaffold containing BET for skin injury. The present study suggests that the use of a modified PP mesh can induce tissue regeneration and accelerate wound healing at the skin injury site.
format	article
author	Leila Zahedi Pedram Ghourchi Beigi Mojtaba Shafiee Fatemeh Zare Hamed Mahdikia Majid Abdouss Mohammad-Amin Abdollahifar Babak Shokri
author_facet	Leila Zahedi Pedram Ghourchi Beigi Mojtaba Shafiee Fatemeh Zare Hamed Mahdikia Majid Abdouss Mohammad-Amin Abdollahifar Babak Shokri
author_sort	Leila Zahedi
title	Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
title_short	Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
title_full	Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
title_fullStr	Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
title_full_unstemmed	Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
title_sort	development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/447f723ff31b4227815b123639bb59e1
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Development of plasma functionalized polypropylene wound dressing for betaine hydrochloride controlled drug delivery on diabetic wounds

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