The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex

Abstract The actin binding protein drebrin plays a key role in dendritic spine formation and synaptic plasticity. Decreased drebrin protein levels have been observed in temporal lobe epilepsy, suggesting the involvement of drebrin in the disease. Here we investigated the effect of drebrin knockout o...

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Autores principales:	Alexander Klemz, Patricia Kreis, Britta J. Eickholt, Zoltan Gerevich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/447fb8a582014b5c8236b734ce3f5c13
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spelling	oai:doaj.org-article:447fb8a582014b5c8236b734ce3f5c132021-12-02T15:27:05ZThe actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex10.1038/s41598-021-87967-52045-2322https://doaj.org/article/447fb8a582014b5c8236b734ce3f5c132021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87967-5https://doaj.org/toc/2045-2322Abstract The actin binding protein drebrin plays a key role in dendritic spine formation and synaptic plasticity. Decreased drebrin protein levels have been observed in temporal lobe epilepsy, suggesting the involvement of drebrin in the disease. Here we investigated the effect of drebrin knockout on physiological and pathophysiological neuronal network activities in mice by inducing gamma oscillations, involved in higher cognitive functions, and by analyzing pathophysiological epileptiform activity. We found that loss of drebrin increased the emergence of spontaneous gamma oscillations suggesting an increase in neuronal excitability when drebrin is absent. Further analysis showed that although the kainate-induced hippocampal gamma oscillations were unchanged in drebrin deficient mice, seizure like events measured in the entorhinal cortex appeared earlier and more frequently. The results suggest that while drebrin is not essential for normal physiological network activity, it helps to protect against the formation of seizure like activities during pathological conditions. The data indicate that targeting drebrin function could potentially be a preventive or therapeutic strategy for epilepsy treatment.Alexander KlemzPatricia KreisBritta J. EickholtZoltan GerevichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Klemz Patricia Kreis Britta J. Eickholt Zoltan Gerevich The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
description	Abstract The actin binding protein drebrin plays a key role in dendritic spine formation and synaptic plasticity. Decreased drebrin protein levels have been observed in temporal lobe epilepsy, suggesting the involvement of drebrin in the disease. Here we investigated the effect of drebrin knockout on physiological and pathophysiological neuronal network activities in mice by inducing gamma oscillations, involved in higher cognitive functions, and by analyzing pathophysiological epileptiform activity. We found that loss of drebrin increased the emergence of spontaneous gamma oscillations suggesting an increase in neuronal excitability when drebrin is absent. Further analysis showed that although the kainate-induced hippocampal gamma oscillations were unchanged in drebrin deficient mice, seizure like events measured in the entorhinal cortex appeared earlier and more frequently. The results suggest that while drebrin is not essential for normal physiological network activity, it helps to protect against the formation of seizure like activities during pathological conditions. The data indicate that targeting drebrin function could potentially be a preventive or therapeutic strategy for epilepsy treatment.
format	article
author	Alexander Klemz Patricia Kreis Britta J. Eickholt Zoltan Gerevich
author_facet	Alexander Klemz Patricia Kreis Britta J. Eickholt Zoltan Gerevich
author_sort	Alexander Klemz
title	The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
title_short	The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
title_full	The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
title_fullStr	The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
title_full_unstemmed	The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
title_sort	actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/447fb8a582014b5c8236b734ce3f5c13
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The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex

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