Systane® lubricant eye drops in the management of ocular dryness

Umberto BenelliDepartment of Neurosciences, Section of Ophthalmology, University of Pisa, Pisa, ItalyAbstract: The understanding of dry eye disease has advanced recently through increasing recognition that the etiology of the condition involves both tear evaporation and insufficient tear production,...

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Autor principal: Benelli U
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Lenguaje:EN
Publicado: Dove Medical Press 2011
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spelling oai:doaj.org-article:448793201b744503a0a5eda672a1629a2021-12-02T01:55:48ZSystane® lubricant eye drops in the management of ocular dryness1177-54671177-5483https://doaj.org/article/448793201b744503a0a5eda672a1629a2011-06-01T00:00:00Zhttp://www.dovepress.com/systanereg-lubricant-eye-drops-in-the-management-of-ocular-dryness-a7630https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Umberto BenelliDepartment of Neurosciences, Section of Ophthalmology, University of Pisa, Pisa, ItalyAbstract: The understanding of dry eye disease has advanced recently through increasing recognition that the etiology of the condition involves both tear evaporation and insufficient tear production, and that tear film instability and inflammation play roles in the various stages of the disease. Of significance, it has been recognized that lipid layer thickness correlates with tear film stability. The management of dry eye involves various strategies and therapeutic approaches that address one or more etiopathological components of the disease. The purpose of this review is to outline the characteristics and clinical utility of the Systane® ocular lubricants that contain hydroxypropyl-guar and one or both of the demulcents, ie, polyethylene glycol 400 and propylene glycol. Clinically, these products are safe and are indicated for the temporary relief of burning and irritation due to dryness of the eye. In particular, this review describes the formulations, mechanisms of action, and clinical utility of the newest additions to this topical ocular lubricant family, Systane Ultra® and Systane Balance®. Both of these ocular products are formulated with an intelligent delivery system and both provide symptomatic relief to patients with dry eye. However, Systane Balance is a novel formulation that contains both polymer and lipid components designed to protect the ocular surface and replenish tear film lipids simultaneously, a factor that is of particular relevance to patients who have dry eye associated with meibomian gland dysfunction.Keywords: Systane Ultra, Systane Balance, dry eye, hydroxypropyl-guar, meibomian gland dysfunction, dimyristoylphosphatidylglycerol Benelli UDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 783-790 (2011)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Benelli U
Systane® lubricant eye drops in the management of ocular dryness
description Umberto BenelliDepartment of Neurosciences, Section of Ophthalmology, University of Pisa, Pisa, ItalyAbstract: The understanding of dry eye disease has advanced recently through increasing recognition that the etiology of the condition involves both tear evaporation and insufficient tear production, and that tear film instability and inflammation play roles in the various stages of the disease. Of significance, it has been recognized that lipid layer thickness correlates with tear film stability. The management of dry eye involves various strategies and therapeutic approaches that address one or more etiopathological components of the disease. The purpose of this review is to outline the characteristics and clinical utility of the Systane® ocular lubricants that contain hydroxypropyl-guar and one or both of the demulcents, ie, polyethylene glycol 400 and propylene glycol. Clinically, these products are safe and are indicated for the temporary relief of burning and irritation due to dryness of the eye. In particular, this review describes the formulations, mechanisms of action, and clinical utility of the newest additions to this topical ocular lubricant family, Systane Ultra® and Systane Balance®. Both of these ocular products are formulated with an intelligent delivery system and both provide symptomatic relief to patients with dry eye. However, Systane Balance is a novel formulation that contains both polymer and lipid components designed to protect the ocular surface and replenish tear film lipids simultaneously, a factor that is of particular relevance to patients who have dry eye associated with meibomian gland dysfunction.Keywords: Systane Ultra, Systane Balance, dry eye, hydroxypropyl-guar, meibomian gland dysfunction, dimyristoylphosphatidylglycerol 
format article
author Benelli U
author_facet Benelli U
author_sort Benelli U
title Systane® lubricant eye drops in the management of ocular dryness
title_short Systane® lubricant eye drops in the management of ocular dryness
title_full Systane® lubricant eye drops in the management of ocular dryness
title_fullStr Systane® lubricant eye drops in the management of ocular dryness
title_full_unstemmed Systane® lubricant eye drops in the management of ocular dryness
title_sort systane® lubricant eye drops in the management of ocular dryness
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/448793201b744503a0a5eda672a1629a
work_keys_str_mv AT benelliu systaneampreglubricanteyedropsinthemanagementofoculardryness
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