p-STAT3 is a PDC-E2 interacting partner in human cholangiocytes and hepatocytes with potential pathobiological implications

Abstract The E2 component of the mitochondrial pyruvate dehydrogenase complex (PDC) is the key autoantigen in primary biliary cholangitis (PBC) and STAT3 is an inflammatory modulator that participates in the pathogenesis of many liver diseases. This study investigated whether PDC-E2 interacts with S...

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Autores principales: Ewa Kilanczyk, Jesus M. Banales, Ewelina Jurewicz, Piotr Milkiewicz, Malgorzata Milkiewicz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/448ba08a08194eda9938316dd1e5129b
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