Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model

Lijun Zhang,1 Jianyang Liu,1 Yingbin Ge,2 Meiyan Liu1 1Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, People’s Republic of China; 2Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 211166, People’s...

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Autores principales:	Zhang L, Liu J, Ge Y, Liu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	heart failure inflammation 5-ht apoptosis depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/448bede60e444413aa55a1b75106ae54
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spelling	oai:doaj.org-article:448bede60e444413aa55a1b75106ae542021-12-02T04:07:45ZGinkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model1178-2021https://doaj.org/article/448bede60e444413aa55a1b75106ae542019-10-01T00:00:00Zhttps://www.dovepress.com/ginkgo-biloba-extract-reduces-hippocampus-inflammatory-responses-impro-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lijun Zhang,1 Jianyang Liu,1 Yingbin Ge,2 Meiyan Liu1 1Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, People’s Republic of China; 2Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 211166, People’s Republic of ChinaCorrespondence: Meiyan LiuDepartment of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, People’s Republic of ChinaEmail liumeiyanaz@163.comBackground: Depression has been shown to share an extremely high comorbidity with heart failure (HF). Ginkgo biloba extract (GBE) is a widely used traditional Chinese medicine in cardiac disease. However, its potential therapeutic effect on depressive symptoms following HF largely remains unknown. In this article, we aimed to investigate its effects in reducing depressive behaviors of a HF mouse model. Moreover, we also discussed whether its effects are associated with changes in neural inflammation and 5-hydroxytryptamine (5-HT) signaling.Methods: Mice were randomly divided into three groups: sham, HF+saline and HF+GBE (150 mg/kg/d) (n=10 per group). Systolic heart failure was induced by ligating the left anterior descending coronary artery. Cardiac functions together with depressive-like behaviors were measured after 4 weeks’ treatment. Levels of brain natriuretic peptide (BNP), 5-HT, 5-HT receptor 2A (5-HT2AR), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), vascular endothelial growth factor (VEGF), hypoxia inducible factor-1 (HIF-1), (cleaved) caspase-3, Bax and Bcl-2 were analyzed by Western blot, Elisa and immunohistochemistry at the end of the experiments.Results: GBE benefited antidepressant-like behaviors and improved cardiac functions in mice with heart failure. Levels of TNF-α, IL-1β and 5-HT were reduced in the hippocampus after the administration of GBE. Further experiments revealed that GBE also blocked the release of serotonin in the peripheral blood and triggered HIF-1 induced anti-apoptotic pathways.Conclusion: GBE has potential therapeutic effects in relieving depressive status of patients with HF.Keywords: heart failure, inflammation, 5-HT, apoptosis, depressionZhang LLiu JGe YLiu MDove Medical Pressarticleheart failureinflammation5-htapoptosisdepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3041-3050 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart failure inflammation 5-ht apoptosis depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	heart failure inflammation 5-ht apoptosis depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang L Liu J Ge Y Liu M Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model
description	Lijun Zhang,1 Jianyang Liu,1 Yingbin Ge,2 Meiyan Liu1 1Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, People’s Republic of China; 2Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 211166, People’s Republic of ChinaCorrespondence: Meiyan LiuDepartment of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, People’s Republic of ChinaEmail liumeiyanaz@163.comBackground: Depression has been shown to share an extremely high comorbidity with heart failure (HF). Ginkgo biloba extract (GBE) is a widely used traditional Chinese medicine in cardiac disease. However, its potential therapeutic effect on depressive symptoms following HF largely remains unknown. In this article, we aimed to investigate its effects in reducing depressive behaviors of a HF mouse model. Moreover, we also discussed whether its effects are associated with changes in neural inflammation and 5-hydroxytryptamine (5-HT) signaling.Methods: Mice were randomly divided into three groups: sham, HF+saline and HF+GBE (150 mg/kg/d) (n=10 per group). Systolic heart failure was induced by ligating the left anterior descending coronary artery. Cardiac functions together with depressive-like behaviors were measured after 4 weeks’ treatment. Levels of brain natriuretic peptide (BNP), 5-HT, 5-HT receptor 2A (5-HT2AR), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), vascular endothelial growth factor (VEGF), hypoxia inducible factor-1 (HIF-1), (cleaved) caspase-3, Bax and Bcl-2 were analyzed by Western blot, Elisa and immunohistochemistry at the end of the experiments.Results: GBE benefited antidepressant-like behaviors and improved cardiac functions in mice with heart failure. Levels of TNF-α, IL-1β and 5-HT were reduced in the hippocampus after the administration of GBE. Further experiments revealed that GBE also blocked the release of serotonin in the peripheral blood and triggered HIF-1 induced anti-apoptotic pathways.Conclusion: GBE has potential therapeutic effects in relieving depressive status of patients with HF.Keywords: heart failure, inflammation, 5-HT, apoptosis, depression
format	article
author	Zhang L Liu J Ge Y Liu M
author_facet	Zhang L Liu J Ge Y Liu M
author_sort	Zhang L
title	Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model
title_short	Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model
title_full	Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model
title_fullStr	Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model
title_full_unstemmed	Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model
title_sort	ginkgo biloba extract reduces hippocampus inflammatory responses, improves cardiac functions and depressive behaviors in a heart failure mouse model
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/448bede60e444413aa55a1b75106ae54
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Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model

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