Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

The family of DNA methyltransferases (Dnmts) consists of four catalytically active enzymes that catalyze DNA methylation and also play a role as transcriptional regulators. Here the authors show that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absenc...

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Autores principales:	Pawel Nowialis, Katarina Lopusna, Jana Opavska, Staci L. Haney, Ajay Abraham, Peike Sheng, Alberto Riva, Amarnath Natarajan, Olga Guryanova, Melanie Simpson, Ryan Hlady, Mingyi Xie, Rene Opavsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/448fa71be0454ca58fa8000cb56d8459
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spelling	oai:doaj.org-article:448fa71be0454ca58fa8000cb56d84592021-12-02T14:38:44ZCatalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions10.1038/s41467-019-12355-72041-1723https://doaj.org/article/448fa71be0454ca58fa8000cb56d84592019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12355-7https://doaj.org/toc/2041-1723The family of DNA methyltransferases (Dnmts) consists of four catalytically active enzymes that catalyze DNA methylation and also play a role as transcriptional regulators. Here the authors show that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absence of Dnmt3b during mouse embryonic development.Pawel NowialisKatarina LopusnaJana OpavskaStaci L. HaneyAjay AbrahamPeike ShengAlberto RivaAmarnath NatarajanOlga GuryanovaMelanie SimpsonRyan HladyMingyi XieRene OpavskyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pawel Nowialis Katarina Lopusna Jana Opavska Staci L. Haney Ajay Abraham Peike Sheng Alberto Riva Amarnath Natarajan Olga Guryanova Melanie Simpson Ryan Hlady Mingyi Xie Rene Opavsky Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
description	The family of DNA methyltransferases (Dnmts) consists of four catalytically active enzymes that catalyze DNA methylation and also play a role as transcriptional regulators. Here the authors show that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absence of Dnmt3b during mouse embryonic development.
format	article
author	Pawel Nowialis Katarina Lopusna Jana Opavska Staci L. Haney Ajay Abraham Peike Sheng Alberto Riva Amarnath Natarajan Olga Guryanova Melanie Simpson Ryan Hlady Mingyi Xie Rene Opavsky
author_facet	Pawel Nowialis Katarina Lopusna Jana Opavska Staci L. Haney Ajay Abraham Peike Sheng Alberto Riva Amarnath Natarajan Olga Guryanova Melanie Simpson Ryan Hlady Mingyi Xie Rene Opavsky
author_sort	Pawel Nowialis
title	Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
title_short	Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
title_full	Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
title_fullStr	Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
title_full_unstemmed	Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
title_sort	catalytically inactive dnmt3b rescues mouse embryonic development by accessory and repressive functions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/448fa71be0454ca58fa8000cb56d8459
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Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

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