A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.

<h4>Background</h4>Compared with invasive breast cancer, breast cancer in situ (BCIS) is seldom life threatening. However, an increasing incidence has been observed in recent years over the world. The purpose of our study is to investigate the epidemiological, clinical and pathological p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanan Kong, Lu Yang, Hailin Tang, Ning Lv, Xinhua Xie, Jing Li, Jiaoli Guo, Laisheng Li, Minqin Wu, Jie Gao, Hongjian Yang, Zhonghua Tang, Jianjun He, Bin Zhang, Hui Li, Youlin Qiao, Xiaoming Xie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4494a423d6544c1ebbf58e154698935c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4494a423d6544c1ebbf58e154698935c
record_format	dspace
spelling	oai:doaj.org-article:4494a423d6544c1ebbf58e154698935c2021-11-18T08:45:23ZA nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.1932-620310.1371/journal.pone.0081055https://doaj.org/article/4494a423d6544c1ebbf58e154698935c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278375/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Compared with invasive breast cancer, breast cancer in situ (BCIS) is seldom life threatening. However, an increasing incidence has been observed in recent years over the world. The purpose of our study is to investigate the epidemiological, clinical and pathological profiles of BCIS in Chinese women from 1999-2008.<h4>Methods</h4>Four thousand and two hundred-eleven female breast cancer (BC) patients were enrolled in this hospital-based nation-wide and multi-center retrospective study. Patients were randomly selected from seven hospitals in seven representative geographical regions of China between 1999 and 2008. The epidemiological, clinical and pathological data were collected based on the designed case report form (CRF).<h4>Results</h4>There were one hundred and forty-three BCIS cases in four thousand and two hundred-eleven BC patients (3.4%). The mean age at diagnosis was 48.3 years and BCIS peaked in age group 40-49 yrs (39.9%). The most common subtype was ductal carcinoma in situ (DCIS) (88.0%). 53.8% were positive for estrogen receptor (ER). Human epidermal growth factor receptor 2 (HER2) positive status was observed in 23.8% of patients. All patients underwent surgeries and 14.7% of them had breast conservation therapies (BCT) (21/143), but 41.9% accepted chemotherapy (64/143). Much less patients underwent radiotherapy (16.0%, 23/143) and among patients who had BCT, 67% accepted radiotherapy (14/21). Endocrine therapy was taken in 44.1% patients (63/143).<h4>Conclusions</h4>The younger age of BCIS among Chinese women than Western countries and increasing number of cases pose a great challenge. BCT and endocrine therapy are under great needs.Yanan KongLu YangHailin TangNing LvXinhua XieJing LiJiaoli GuoLaisheng LiMinqin WuJie GaoHongjian YangZhonghua TangJianjun HeBin ZhangHui LiYoulin QiaoXiaoming XiePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81055 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanan Kong Lu Yang Hailin Tang Ning Lv Xinhua Xie Jing Li Jiaoli Guo Laisheng Li Minqin Wu Jie Gao Hongjian Yang Zhonghua Tang Jianjun He Bin Zhang Hui Li Youlin Qiao Xiaoming Xie A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
description	<h4>Background</h4>Compared with invasive breast cancer, breast cancer in situ (BCIS) is seldom life threatening. However, an increasing incidence has been observed in recent years over the world. The purpose of our study is to investigate the epidemiological, clinical and pathological profiles of BCIS in Chinese women from 1999-2008.<h4>Methods</h4>Four thousand and two hundred-eleven female breast cancer (BC) patients were enrolled in this hospital-based nation-wide and multi-center retrospective study. Patients were randomly selected from seven hospitals in seven representative geographical regions of China between 1999 and 2008. The epidemiological, clinical and pathological data were collected based on the designed case report form (CRF).<h4>Results</h4>There were one hundred and forty-three BCIS cases in four thousand and two hundred-eleven BC patients (3.4%). The mean age at diagnosis was 48.3 years and BCIS peaked in age group 40-49 yrs (39.9%). The most common subtype was ductal carcinoma in situ (DCIS) (88.0%). 53.8% were positive for estrogen receptor (ER). Human epidermal growth factor receptor 2 (HER2) positive status was observed in 23.8% of patients. All patients underwent surgeries and 14.7% of them had breast conservation therapies (BCT) (21/143), but 41.9% accepted chemotherapy (64/143). Much less patients underwent radiotherapy (16.0%, 23/143) and among patients who had BCT, 67% accepted radiotherapy (14/21). Endocrine therapy was taken in 44.1% patients (63/143).<h4>Conclusions</h4>The younger age of BCIS among Chinese women than Western countries and increasing number of cases pose a great challenge. BCT and endocrine therapy are under great needs.
format	article
author	Yanan Kong Lu Yang Hailin Tang Ning Lv Xinhua Xie Jing Li Jiaoli Guo Laisheng Li Minqin Wu Jie Gao Hongjian Yang Zhonghua Tang Jianjun He Bin Zhang Hui Li Youlin Qiao Xiaoming Xie
author_facet	Yanan Kong Lu Yang Hailin Tang Ning Lv Xinhua Xie Jing Li Jiaoli Guo Laisheng Li Minqin Wu Jie Gao Hongjian Yang Zhonghua Tang Jianjun He Bin Zhang Hui Li Youlin Qiao Xiaoming Xie
author_sort	Yanan Kong
title	A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
title_short	A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
title_full	A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
title_fullStr	A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
title_full_unstemmed	A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.
title_sort	nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in chinese women in 1999 - 2008.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4494a423d6544c1ebbf58e154698935c
work_keys_str_mv	AT yanankong anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT luyang anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT hailintang anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT ninglv anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT xinhuaxie anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jingli anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jiaoliguo anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT laishengli anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT minqinwu anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jiegao anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT hongjianyang anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT zhonghuatang anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jianjunhe anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT binzhang anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT huili anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT youlinqiao anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT xiaomingxie anationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT yanankong nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT luyang nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT hailintang nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT ninglv nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT xinhuaxie nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jingli nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jiaoliguo nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT laishengli nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT minqinwu nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jiegao nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT hongjianyang nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT zhonghuatang nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT jianjunhe nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT binzhang nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT huili nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT youlinqiao nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008 AT xiaomingxie nationwidemulticenterretrospectivestudyoftheepidemiologicalpathologicalandclinicalcharacteristicsofbreastcancerinsituinchinesewomenin19992008
_version_	1718421318375833600

A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.

Ejemplares similares