Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.
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Nature Portfolio
2017
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oai:doaj.org-article:44968fa5d84b440599307b3e8bfee6222021-12-02T17:06:20ZTet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells10.1038/ncomms151022041-1723https://doaj.org/article/44968fa5d84b440599307b3e8bfee6222017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15102https://doaj.org/toc/2041-1723TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.Feng PanThomas S. WingoZhigang ZhaoRui GaoHideki MakishimaGuangbo QuLi LinMiao YuJanice R. OrtegaJiapeng WangAziz NazhaLi ChenBing YaoCan LiuShi ChenOphelia WeeksHongyu NiBrittany Lynn PhillipsSuming HuangJianlong WangChuan HeGuo-Min LiTomas RadivoyevitchIannis AifantisJaroslaw P. MaciejewskiFeng-Chun YangPeng JinMingjiang XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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Science Q Feng Pan Thomas S. Wingo Zhigang Zhao Rui Gao Hideki Makishima Guangbo Qu Li Lin Miao Yu Janice R. Ortega Jiapeng Wang Aziz Nazha Li Chen Bing Yao Can Liu Shi Chen Ophelia Weeks Hongyu Ni Brittany Lynn Phillips Suming Huang Jianlong Wang Chuan He Guo-Min Li Tomas Radivoyevitch Iannis Aifantis Jaroslaw P. Maciejewski Feng-Chun Yang Peng Jin Mingjiang Xu Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| description |
TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells. |
| format |
article |
| author |
Feng Pan Thomas S. Wingo Zhigang Zhao Rui Gao Hideki Makishima Guangbo Qu Li Lin Miao Yu Janice R. Ortega Jiapeng Wang Aziz Nazha Li Chen Bing Yao Can Liu Shi Chen Ophelia Weeks Hongyu Ni Brittany Lynn Phillips Suming Huang Jianlong Wang Chuan He Guo-Min Li Tomas Radivoyevitch Iannis Aifantis Jaroslaw P. Maciejewski Feng-Chun Yang Peng Jin Mingjiang Xu |
| author_facet |
Feng Pan Thomas S. Wingo Zhigang Zhao Rui Gao Hideki Makishima Guangbo Qu Li Lin Miao Yu Janice R. Ortega Jiapeng Wang Aziz Nazha Li Chen Bing Yao Can Liu Shi Chen Ophelia Weeks Hongyu Ni Brittany Lynn Phillips Suming Huang Jianlong Wang Chuan He Guo-Min Li Tomas Radivoyevitch Iannis Aifantis Jaroslaw P. Maciejewski Feng-Chun Yang Peng Jin Mingjiang Xu |
| author_sort |
Feng Pan |
| title |
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| title_short |
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| title_full |
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| title_fullStr |
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| title_full_unstemmed |
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| title_sort |
tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/44968fa5d84b440599307b3e8bfee622 |
| work_keys_str_mv |
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