Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Phuong-Uyen C. Dinh, Dipti Paudel, Hayden Brochu, Kristen D. Popowski, M. Cyndell Gracieux, Jhon Cores, Ke Huang, M. Taylor Hensley, Erin Harrell, Adam C. Vandergriff, Arianna K. George, Raina T. Barrio, Shiqi Hu, Tyler A. Allen, Kevin Blackburn, Thomas G. Caranasos, Xinxia Peng, Lauren V. Schnabel, Kenneth B. Adler, Leonard J. Lobo, Michael B. Goshe, Ke Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4496cdf678834d70ba8a9b30f7098a55
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4496cdf678834d70ba8a9b30f7098a55
record_format	dspace
spelling	oai:doaj.org-article:4496cdf678834d70ba8a9b30f7098a552021-12-02T15:34:35ZInhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis10.1038/s41467-020-14344-72041-1723https://doaj.org/article/4496cdf678834d70ba8a9b30f7098a552020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14344-7https://doaj.org/toc/2041-1723Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.Phuong-Uyen C. DinhDipti PaudelHayden BrochuKristen D. PopowskiM. Cyndell GracieuxJhon CoresKe HuangM. Taylor HensleyErin HarrellAdam C. VandergriffArianna K. GeorgeRaina T. BarrioShiqi HuTyler A. AllenKevin BlackburnThomas G. CaranasosXinxia PengLauren V. SchnabelKenneth B. AdlerLeonard J. LoboMichael B. GosheKe ChengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Phuong-Uyen C. Dinh Dipti Paudel Hayden Brochu Kristen D. Popowski M. Cyndell Gracieux Jhon Cores Ke Huang M. Taylor Hensley Erin Harrell Adam C. Vandergriff Arianna K. George Raina T. Barrio Shiqi Hu Tyler A. Allen Kevin Blackburn Thomas G. Caranasos Xinxia Peng Lauren V. Schnabel Kenneth B. Adler Leonard J. Lobo Michael B. Goshe Ke Cheng Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
description	Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.
format	article
author	Phuong-Uyen C. Dinh Dipti Paudel Hayden Brochu Kristen D. Popowski M. Cyndell Gracieux Jhon Cores Ke Huang M. Taylor Hensley Erin Harrell Adam C. Vandergriff Arianna K. George Raina T. Barrio Shiqi Hu Tyler A. Allen Kevin Blackburn Thomas G. Caranasos Xinxia Peng Lauren V. Schnabel Kenneth B. Adler Leonard J. Lobo Michael B. Goshe Ke Cheng
author_facet	Phuong-Uyen C. Dinh Dipti Paudel Hayden Brochu Kristen D. Popowski M. Cyndell Gracieux Jhon Cores Ke Huang M. Taylor Hensley Erin Harrell Adam C. Vandergriff Arianna K. George Raina T. Barrio Shiqi Hu Tyler A. Allen Kevin Blackburn Thomas G. Caranasos Xinxia Peng Lauren V. Schnabel Kenneth B. Adler Leonard J. Lobo Michael B. Goshe Ke Cheng
author_sort	Phuong-Uyen C. Dinh
title	Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_short	Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_full	Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_fullStr	Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_full_unstemmed	Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_sort	inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4496cdf678834d70ba8a9b30f7098a55
work_keys_str_mv	AT phuonguyencdinh inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT diptipaudel inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT haydenbrochu inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT kristendpopowski inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT mcyndellgracieux inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT jhoncores inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT kehuang inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT mtaylorhensley inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT erinharrell inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT adamcvandergriff inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT ariannakgeorge inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT rainatbarrio inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT shiqihu inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT tyleraallen inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT kevinblackburn inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT thomasgcaranasos inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT xinxiapeng inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT laurenvschnabel inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT kennethbadler inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT leonardjlobo inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT michaelbgoshe inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis AT kecheng inhalationoflungspheroidcellsecretomeandexosomespromoteslungrepairinpulmonaryfibrosis
_version_	1718386778185924608

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Ejemplares similares