The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women

David J Browning, Chong Lee, David Rotberg Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, North Carolina, NC, USA Purpose: To determine how algorithms for ideal body weight (IBW) affect hydroxychloroquine dosing in women.Methods: This was a retrospective study of 520 patients screened...

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Autores principales:	Browning DJ, Lee C, Rotberg D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4498094a889c47bbab552f8f2e6c8d23
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spelling	oai:doaj.org-article:4498094a889c47bbab552f8f2e6c8d232021-12-02T05:52:13ZThe impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women1177-5483https://doaj.org/article/4498094a889c47bbab552f8f2e6c8d232014-07-01T00:00:00Zhttp://www.dovepress.com/the-impact-of-different-algorithms-for-ideal-body-weight-on-screening--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 David J Browning, Chong Lee, David Rotberg Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, North Carolina, NC, USA Purpose: To determine how algorithms for ideal body weight (IBW) affect hydroxychloroquine dosing in women.Methods: This was a retrospective study of 520 patients screened for hydroxychloroquine retinopathy. Charts were reviewed for sex, height, weight, and daily dose. The outcome measures were ranges of IBW across algorithms; rates of potentially toxic dosing; height thresholds below which 400 mg/d dosing is potentially toxic; and rates for which actual body weight (ABW) was less than IBW.Results: Women made up 474 (91%) of the patients. The IBWs for a height varied from 30–34 pounds (13.6–15.5 kg) across algorithms. The threshold heights below which toxic dosing occurred varied from 62–70 inches (157.5–177.8 cm). Different algorithms placed 16%–98% of women in the toxic dosing range. The proportion for whom dosing should have been based on ABW rather than IBW ranged from 5%–31% across algorithms. Conclusion: Although hydroxychloroquine dosing should be based on the lesser of ABW and IBW, there is no consensus about the definition of IBW. The Michaelides algorithm is associated with the most frequent need to adjust dosing; the Metropolitan Life Insurance, large frame, mean value table with the least frequent need. No evidence indicates that one algorithm is superior to others. Keywords: hydroxychloroquine, ideal body weight, actual body weight, toxicity, retinopathy, algorithmsBrowning DJLee CRotberg DDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1401-1407 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Browning DJ Lee C Rotberg D The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
description	David J Browning, Chong Lee, David Rotberg Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, North Carolina, NC, USA Purpose: To determine how algorithms for ideal body weight (IBW) affect hydroxychloroquine dosing in women.Methods: This was a retrospective study of 520 patients screened for hydroxychloroquine retinopathy. Charts were reviewed for sex, height, weight, and daily dose. The outcome measures were ranges of IBW across algorithms; rates of potentially toxic dosing; height thresholds below which 400 mg/d dosing is potentially toxic; and rates for which actual body weight (ABW) was less than IBW.Results: Women made up 474 (91%) of the patients. The IBWs for a height varied from 30–34 pounds (13.6–15.5 kg) across algorithms. The threshold heights below which toxic dosing occurred varied from 62–70 inches (157.5–177.8 cm). Different algorithms placed 16%–98% of women in the toxic dosing range. The proportion for whom dosing should have been based on ABW rather than IBW ranged from 5%–31% across algorithms. Conclusion: Although hydroxychloroquine dosing should be based on the lesser of ABW and IBW, there is no consensus about the definition of IBW. The Michaelides algorithm is associated with the most frequent need to adjust dosing; the Metropolitan Life Insurance, large frame, mean value table with the least frequent need. No evidence indicates that one algorithm is superior to others. Keywords: hydroxychloroquine, ideal body weight, actual body weight, toxicity, retinopathy, algorithms
format	article
author	Browning DJ Lee C Rotberg D
author_facet	Browning DJ Lee C Rotberg D
author_sort	Browning DJ
title	The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
title_short	The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
title_full	The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
title_fullStr	The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
title_full_unstemmed	The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
title_sort	impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/4498094a889c47bbab552f8f2e6c8d23
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The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women

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