Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle

Baba et al. analyzed the transcriptomes from quadriceps type IIB fibers of untreated, gonadectomized, and sex steroid-treated mice of both sexes and identified Pfkfb3 and Pdk4 as differentially regulated genes between males and diestrus females. The authors found that Pfkfb3 and Pdk4 may act as meta...

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Autores principales:	Antonius Christianto, Takashi Baba, Fumiya Takahashi, Kai Inui, Miki Inoue, Mikita Suyama, Yusuke Ono, Yasuyuki Ohkawa, Ken-ichirou Morohashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/44988098e0d94e429ef8c3e6cc06eaf5
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spelling	oai:doaj.org-article:44988098e0d94e429ef8c3e6cc06eaf52021-11-07T12:19:28ZSex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle10.1038/s42003-021-02790-y2399-3642https://doaj.org/article/44988098e0d94e429ef8c3e6cc06eaf52021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02790-yhttps://doaj.org/toc/2399-3642Baba et al. analyzed the transcriptomes from quadriceps type IIB fibers of untreated, gonadectomized, and sex steroid-treated mice of both sexes and identified Pfkfb3 and Pdk4 as differentially regulated genes between males and diestrus females. The authors found that Pfkfb3 and Pdk4 may act as metabolic switches, showed male-enriched and estradiol-enhanced expression, respectively and contributed to sexually dimorphic metabolism.Antonius ChristiantoTakashi BabaFumiya TakahashiKai InuiMiki InoueMikita SuyamaYusuke OnoYasuyuki OhkawaKen-ichirou MorohashiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Antonius Christianto Takashi Baba Fumiya Takahashi Kai Inui Miki Inoue Mikita Suyama Yusuke Ono Yasuyuki Ohkawa Ken-ichirou Morohashi Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
description	Baba et al. analyzed the transcriptomes from quadriceps type IIB fibers of untreated, gonadectomized, and sex steroid-treated mice of both sexes and identified Pfkfb3 and Pdk4 as differentially regulated genes between males and diestrus females. The authors found that Pfkfb3 and Pdk4 may act as metabolic switches, showed male-enriched and estradiol-enhanced expression, respectively and contributed to sexually dimorphic metabolism.
format	article
author	Antonius Christianto Takashi Baba Fumiya Takahashi Kai Inui Miki Inoue Mikita Suyama Yusuke Ono Yasuyuki Ohkawa Ken-ichirou Morohashi
author_facet	Antonius Christianto Takashi Baba Fumiya Takahashi Kai Inui Miki Inoue Mikita Suyama Yusuke Ono Yasuyuki Ohkawa Ken-ichirou Morohashi
author_sort	Antonius Christianto
title	Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
title_short	Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
title_full	Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
title_fullStr	Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
title_full_unstemmed	Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
title_sort	sex differences in metabolic pathways are regulated by pfkfb3 and pdk4 expression in rodent muscle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44988098e0d94e429ef8c3e6cc06eaf5
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Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle

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