Profiling DNA damage response following mitotic perturbations

DNA damage arising from replication stress is well studied, but the effect of mitotic errors on genome integrity is less understood. Here the authors knock down 47 mitotic regulators and record how they impact on DNA breakage events, providing a resource for future studies on the relation between ce...

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Autores principales:	Ronni S. Pedersen, Gopal Karemore, Thorkell Gudjonsson, Maj-Britt Rask, Beate Neumann, Jean-Karim Hériché, Rainer Pepperkok, Jan Ellenberg, Daniel W. Gerlich, Jiri Lukas, Claudia Lukas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44999825db4e41e7abeaf600944f0a5b
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spelling	oai:doaj.org-article:44999825db4e41e7abeaf600944f0a5b2021-12-02T17:31:36ZProfiling DNA damage response following mitotic perturbations10.1038/ncomms138872041-1723https://doaj.org/article/44999825db4e41e7abeaf600944f0a5b2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13887https://doaj.org/toc/2041-1723DNA damage arising from replication stress is well studied, but the effect of mitotic errors on genome integrity is less understood. Here the authors knock down 47 mitotic regulators and record how they impact on DNA breakage events, providing a resource for future studies on the relation between cell division and genome integrity.Ronni S. PedersenGopal KaremoreThorkell GudjonssonMaj-Britt RaskBeate NeumannJean-Karim HérichéRainer PepperkokJan EllenbergDaniel W. GerlichJiri LukasClaudia LukasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ronni S. Pedersen Gopal Karemore Thorkell Gudjonsson Maj-Britt Rask Beate Neumann Jean-Karim Hériché Rainer Pepperkok Jan Ellenberg Daniel W. Gerlich Jiri Lukas Claudia Lukas Profiling DNA damage response following mitotic perturbations
description	DNA damage arising from replication stress is well studied, but the effect of mitotic errors on genome integrity is less understood. Here the authors knock down 47 mitotic regulators and record how they impact on DNA breakage events, providing a resource for future studies on the relation between cell division and genome integrity.
format	article
author	Ronni S. Pedersen Gopal Karemore Thorkell Gudjonsson Maj-Britt Rask Beate Neumann Jean-Karim Hériché Rainer Pepperkok Jan Ellenberg Daniel W. Gerlich Jiri Lukas Claudia Lukas
author_facet	Ronni S. Pedersen Gopal Karemore Thorkell Gudjonsson Maj-Britt Rask Beate Neumann Jean-Karim Hériché Rainer Pepperkok Jan Ellenberg Daniel W. Gerlich Jiri Lukas Claudia Lukas
author_sort	Ronni S. Pedersen
title	Profiling DNA damage response following mitotic perturbations
title_short	Profiling DNA damage response following mitotic perturbations
title_full	Profiling DNA damage response following mitotic perturbations
title_fullStr	Profiling DNA damage response following mitotic perturbations
title_full_unstemmed	Profiling DNA damage response following mitotic perturbations
title_sort	profiling dna damage response following mitotic perturbations
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/44999825db4e41e7abeaf600944f0a5b
work_keys_str_mv	AT ronnispedersen profilingdnadamageresponsefollowingmitoticperturbations AT gopalkaremore profilingdnadamageresponsefollowingmitoticperturbations AT thorkellgudjonsson profilingdnadamageresponsefollowingmitoticperturbations AT majbrittrask profilingdnadamageresponsefollowingmitoticperturbations AT beateneumann profilingdnadamageresponsefollowingmitoticperturbations AT jeankarimheriche profilingdnadamageresponsefollowingmitoticperturbations AT rainerpepperkok profilingdnadamageresponsefollowingmitoticperturbations AT janellenberg profilingdnadamageresponsefollowingmitoticperturbations AT danielwgerlich profilingdnadamageresponsefollowingmitoticperturbations AT jirilukas profilingdnadamageresponsefollowingmitoticperturbations AT claudialukas profilingdnadamageresponsefollowingmitoticperturbations
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Profiling DNA damage response following mitotic perturbations

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