The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.

Intestinal microbiota is related to obesity and serum lipid levels, both risk factors for chronic diseases constituting a challenge for public health. We investigated how a diet rich in whole grain (WG) products and red meat (RM) influences microbiota. During a 10-week crossover intervention study,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jana Foerster, Gertraud Maskarinec, Nicole Reichardt, Adrian Tett, Arjan Narbad, Michael Blaut, Heiner Boeing
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/449ae4b18dc5436ba24cd71a52a9062e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:449ae4b18dc5436ba24cd71a52a9062e
record_format	dspace
spelling	oai:doaj.org-article:449ae4b18dc5436ba24cd71a52a9062e2021-11-25T05:57:15ZThe influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.1932-620310.1371/journal.pone.0109606https://doaj.org/article/449ae4b18dc5436ba24cd71a52a9062e2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109606https://doaj.org/toc/1932-6203Intestinal microbiota is related to obesity and serum lipid levels, both risk factors for chronic diseases constituting a challenge for public health. We investigated how a diet rich in whole grain (WG) products and red meat (RM) influences microbiota. During a 10-week crossover intervention study, 20 healthy adults consumed two isocaloric diets, one rich in WG products and one high in RM. Repeatedly data on microbiota were assessed by 16S rRNA based denaturing gradient gel electrophoresis (DGGE). A blood sample and anthropometric data were collected. Mixed models and logistic regression were used to investigate effects. Microbiota showed interindividual variability. However, dietary interventions modified microbiota appearance: 8 bands changed in at least 4 participants during the interventions. One of the bands appearing after WG and one increasing after RM remained significant in regression models and were identified as Collinsella aerofaciens and Clostridium sp. The WG intervention lowered obesity parameters, while the RM diet increased serum levels of uric acid and creatinine. The study showed that diet is a component of major relevance regarding its influence on intestinal microbiota and that WG has an important role for health. The results could guide investigations of diet and microbiota in observational prospective cohort studies. Trial registration: ClinicalTrials.gov NCT01449383.Jana FoersterGertraud MaskarinecNicole ReichardtAdrian TettArjan NarbadMichael BlautHeiner BoeingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109606 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jana Foerster Gertraud Maskarinec Nicole Reichardt Adrian Tett Arjan Narbad Michael Blaut Heiner Boeing The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
description	Intestinal microbiota is related to obesity and serum lipid levels, both risk factors for chronic diseases constituting a challenge for public health. We investigated how a diet rich in whole grain (WG) products and red meat (RM) influences microbiota. During a 10-week crossover intervention study, 20 healthy adults consumed two isocaloric diets, one rich in WG products and one high in RM. Repeatedly data on microbiota were assessed by 16S rRNA based denaturing gradient gel electrophoresis (DGGE). A blood sample and anthropometric data were collected. Mixed models and logistic regression were used to investigate effects. Microbiota showed interindividual variability. However, dietary interventions modified microbiota appearance: 8 bands changed in at least 4 participants during the interventions. One of the bands appearing after WG and one increasing after RM remained significant in regression models and were identified as Collinsella aerofaciens and Clostridium sp. The WG intervention lowered obesity parameters, while the RM diet increased serum levels of uric acid and creatinine. The study showed that diet is a component of major relevance regarding its influence on intestinal microbiota and that WG has an important role for health. The results could guide investigations of diet and microbiota in observational prospective cohort studies. Trial registration: ClinicalTrials.gov NCT01449383.
format	article
author	Jana Foerster Gertraud Maskarinec Nicole Reichardt Adrian Tett Arjan Narbad Michael Blaut Heiner Boeing
author_facet	Jana Foerster Gertraud Maskarinec Nicole Reichardt Adrian Tett Arjan Narbad Michael Blaut Heiner Boeing
author_sort	Jana Foerster
title	The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
title_short	The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
title_full	The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
title_fullStr	The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
title_full_unstemmed	The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
title_sort	influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/449ae4b18dc5436ba24cd71a52a9062e
work_keys_str_mv	AT janafoerster theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT gertraudmaskarinec theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT nicolereichardt theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT adriantett theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT arjannarbad theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT michaelblaut theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT heinerboeing theinfluenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT janafoerster influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT gertraudmaskarinec influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT nicolereichardt influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT adriantett influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT arjannarbad influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT michaelblaut influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial AT heinerboeing influenceofwholegrainproductsandredmeatonintestinalmicrobiotacompositioninnormalweightadultsarandomizedcrossoverinterventiontrial
_version_	1718414334125670400

The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial.

Ejemplares similares