The Role and Clinical Potentials of Circular RNAs in Prostate Cancer

Globally, prostate cancer (PCa) is the second most commonly diagnosed cancer in men globally. Early diagnosis may help in promoting survival in the affected patients. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) which have been found to show extensive dysregulation in a han...

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Autores principales:	Mohammad Taheri, Sajad Najafi, Abbas Basiri, Bashdar Mahmud Hussen, Aria Baniahmad, Elena Jamali, Soudeh Ghafouri-Fard
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circular RNAs prostate cancer diagnosis prognosis biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/449c5ab885264f10828811f6baae531c
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spelling	oai:doaj.org-article:449c5ab885264f10828811f6baae531c2021-11-05T11:32:45ZThe Role and Clinical Potentials of Circular RNAs in Prostate Cancer2234-943X10.3389/fonc.2021.781414https://doaj.org/article/449c5ab885264f10828811f6baae531c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.781414/fullhttps://doaj.org/toc/2234-943XGlobally, prostate cancer (PCa) is the second most commonly diagnosed cancer in men globally. Early diagnosis may help in promoting survival in the affected patients. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) which have been found to show extensive dysregulation in a handful of human diseases including cancers. Progressions in RNA identification techniques have provided a vast number of circRNAs exhibiting either up-regulation or down-regulation in PCa tissues compared to normal adjacent tissues. The mechanism of action is not clear for most of dysregulated circRNAs. Among them, function of a number of newly identified dysregulated circRNAs have been assessed in PCa cells. Increase in cell proliferation, migration, invasion, and metastasis have been reported for up-regulated circRNAs which suggest their role as oncogenes. On the other hand, down-regulated circRNAs have shown tumor suppressing actions in experimental studies. Furthermore, in a majority of studies, circRNAs have been found to sponge microRNAs (miRNAs), negatively regulating expression or activity of the downstream miRNAs. Additionally, they have been identified in interaction with regulatory proteins. This axis consequently regulates a signaling pathway, a tumor suppressor, or an oncogene. Easy, quick, and reliable detection of circRNAs in human body fluids also suggests their potentials as biomarker candidates for diagnosis and prediction of prognosis in PCa patients. In this review, we have discussed the role and potentials of a number of dysregulated circRNAs in PCa.Mohammad TaheriSajad NajafiAbbas BasiriBashdar Mahmud HussenAria BaniahmadElena JamaliSoudeh Ghafouri-FardFrontiers Media S.A.articlecircular RNAsprostate cancerdiagnosisprognosisbiomarkerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular RNAs prostate cancer diagnosis prognosis biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	circular RNAs prostate cancer diagnosis prognosis biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mohammad Taheri Sajad Najafi Abbas Basiri Bashdar Mahmud Hussen Aria Baniahmad Elena Jamali Soudeh Ghafouri-Fard The Role and Clinical Potentials of Circular RNAs in Prostate Cancer
description	Globally, prostate cancer (PCa) is the second most commonly diagnosed cancer in men globally. Early diagnosis may help in promoting survival in the affected patients. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) which have been found to show extensive dysregulation in a handful of human diseases including cancers. Progressions in RNA identification techniques have provided a vast number of circRNAs exhibiting either up-regulation or down-regulation in PCa tissues compared to normal adjacent tissues. The mechanism of action is not clear for most of dysregulated circRNAs. Among them, function of a number of newly identified dysregulated circRNAs have been assessed in PCa cells. Increase in cell proliferation, migration, invasion, and metastasis have been reported for up-regulated circRNAs which suggest their role as oncogenes. On the other hand, down-regulated circRNAs have shown tumor suppressing actions in experimental studies. Furthermore, in a majority of studies, circRNAs have been found to sponge microRNAs (miRNAs), negatively regulating expression or activity of the downstream miRNAs. Additionally, they have been identified in interaction with regulatory proteins. This axis consequently regulates a signaling pathway, a tumor suppressor, or an oncogene. Easy, quick, and reliable detection of circRNAs in human body fluids also suggests their potentials as biomarker candidates for diagnosis and prediction of prognosis in PCa patients. In this review, we have discussed the role and potentials of a number of dysregulated circRNAs in PCa.
format	article
author	Mohammad Taheri Sajad Najafi Abbas Basiri Bashdar Mahmud Hussen Aria Baniahmad Elena Jamali Soudeh Ghafouri-Fard
author_facet	Mohammad Taheri Sajad Najafi Abbas Basiri Bashdar Mahmud Hussen Aria Baniahmad Elena Jamali Soudeh Ghafouri-Fard
author_sort	Mohammad Taheri
title	The Role and Clinical Potentials of Circular RNAs in Prostate Cancer
title_short	The Role and Clinical Potentials of Circular RNAs in Prostate Cancer
title_full	The Role and Clinical Potentials of Circular RNAs in Prostate Cancer
title_fullStr	The Role and Clinical Potentials of Circular RNAs in Prostate Cancer
title_full_unstemmed	The Role and Clinical Potentials of Circular RNAs in Prostate Cancer
title_sort	role and clinical potentials of circular rnas in prostate cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/449c5ab885264f10828811f6baae531c
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The Role and Clinical Potentials of Circular RNAs in Prostate Cancer

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