The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis

The metaphor of an adaptive landscape is presented quantitatively by looking at molecular adaptations and their catalytic consequences in a recently evolved bacterial enzyme. The study identifies both genotype-by-environment interactions and environment-dependent epistasis as factors that can alter...

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Autores principales:	Dave W. Anderson, Florian Baier, Gloria Yang, Nobuhiko Tokuriki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44a0b8b6361c40a7b937ffbaa42ff7e2
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spelling	oai:doaj.org-article:44a0b8b6361c40a7b937ffbaa42ff7e22021-12-02T18:02:47ZThe adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis10.1038/s41467-021-23943-x2041-1723https://doaj.org/article/44a0b8b6361c40a7b937ffbaa42ff7e22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23943-xhttps://doaj.org/toc/2041-1723The metaphor of an adaptive landscape is presented quantitatively by looking at molecular adaptations and their catalytic consequences in a recently evolved bacterial enzyme. The study identifies both genotype-by-environment interactions and environment-dependent epistasis as factors that can alter the fitness of functional mutations.Dave W. AndersonFlorian BaierGloria YangNobuhiko TokurikiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dave W. Anderson Florian Baier Gloria Yang Nobuhiko Tokuriki The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
description	The metaphor of an adaptive landscape is presented quantitatively by looking at molecular adaptations and their catalytic consequences in a recently evolved bacterial enzyme. The study identifies both genotype-by-environment interactions and environment-dependent epistasis as factors that can alter the fitness of functional mutations.
format	article
author	Dave W. Anderson Florian Baier Gloria Yang Nobuhiko Tokuriki
author_facet	Dave W. Anderson Florian Baier Gloria Yang Nobuhiko Tokuriki
author_sort	Dave W. Anderson
title	The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
title_short	The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
title_full	The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
title_fullStr	The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
title_full_unstemmed	The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
title_sort	adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44a0b8b6361c40a7b937ffbaa42ff7e2
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The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis

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