The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis
The metaphor of an adaptive landscape is presented quantitatively by looking at molecular adaptations and their catalytic consequences in a recently evolved bacterial enzyme. The study identifies both genotype-by-environment interactions and environment-dependent epistasis as factors that can alter...
Enregistré dans:
Auteurs principaux: | Dave W. Anderson, Florian Baier, Gloria Yang, Nobuhiko Tokuriki |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/44a0b8b6361c40a7b937ffbaa42ff7e2 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Epistasis shapes the fitness landscape of an allosteric specificity switch
par: Kyle K. Nishikawa, et autres
Publié: (2021) -
Human metallo-β-lactamase enzymes degrade penicillin
par: Seydina M. Diene, et autres
Publié: (2019) -
A metallo-β-lactamase enzyme for internal detoxification of the antibiotic thienamycin
par: Seydina M. Diene, et autres
Publié: (2021) -
Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates
par: David Heckmann, et autres
Publié: (2018) -
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
par: Stephane Emond, et autres
Publié: (2020)