Aerosols transmit prions to immunocompetent and immunodeficient mice.

Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 t...

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Autores principales:	Johannes Haybaeck, Mathias Heikenwalder, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J Fuchs, Lothar Stitz, Adriano Aguzzi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/44a0f9c403d646aa858e3bdebcca0adf
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spelling	oai:doaj.org-article:44a0f9c403d646aa858e3bdebcca0adf2021-11-18T06:03:40ZAerosols transmit prions to immunocompetent and immunodeficient mice.1553-73661553-737410.1371/journal.ppat.1001257https://doaj.org/article/44a0f9c403d646aa858e3bdebcca0adf2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21249178/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 transgenic mice overexpressing PrP(C), efficiently develop scrapie upon exposure to aerosolized prions. NSE-PrP transgenic mice, which express PrP(C) selectively in neurons, were also susceptible to airborne prions. Aerogenic infection occurred also in mice lacking B- and T-lymphocytes, NK-cells, follicular dendritic cells or complement components. Brains of diseased mice contained PrP(Sc) and transmitted scrapie when inoculated into further mice. We conclude that aerogenic exposure to prions is very efficacious and can lead to direct invasion of neural pathways without an obligatory replicative phase in lymphoid organs. This previously unappreciated risk for airborne prion transmission may warrant re-thinking on prion biosafety guidelines in research and diagnostic laboratories.Johannes HaybaeckMathias HeikenwalderBritta KlevenzPetra SchwarzIlan MargalithClaire BridelKirsten MertzElizabeta ZirdumBenjamin PetschThomas J FuchsLothar StitzAdriano AguzziPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 1, p e1001257 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Johannes Haybaeck Mathias Heikenwalder Britta Klevenz Petra Schwarz Ilan Margalith Claire Bridel Kirsten Mertz Elizabeta Zirdum Benjamin Petsch Thomas J Fuchs Lothar Stitz Adriano Aguzzi Aerosols transmit prions to immunocompetent and immunodeficient mice.
description	Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 transgenic mice overexpressing PrP(C), efficiently develop scrapie upon exposure to aerosolized prions. NSE-PrP transgenic mice, which express PrP(C) selectively in neurons, were also susceptible to airborne prions. Aerogenic infection occurred also in mice lacking B- and T-lymphocytes, NK-cells, follicular dendritic cells or complement components. Brains of diseased mice contained PrP(Sc) and transmitted scrapie when inoculated into further mice. We conclude that aerogenic exposure to prions is very efficacious and can lead to direct invasion of neural pathways without an obligatory replicative phase in lymphoid organs. This previously unappreciated risk for airborne prion transmission may warrant re-thinking on prion biosafety guidelines in research and diagnostic laboratories.
format	article
author	Johannes Haybaeck Mathias Heikenwalder Britta Klevenz Petra Schwarz Ilan Margalith Claire Bridel Kirsten Mertz Elizabeta Zirdum Benjamin Petsch Thomas J Fuchs Lothar Stitz Adriano Aguzzi
author_facet	Johannes Haybaeck Mathias Heikenwalder Britta Klevenz Petra Schwarz Ilan Margalith Claire Bridel Kirsten Mertz Elizabeta Zirdum Benjamin Petsch Thomas J Fuchs Lothar Stitz Adriano Aguzzi
author_sort	Johannes Haybaeck
title	Aerosols transmit prions to immunocompetent and immunodeficient mice.
title_short	Aerosols transmit prions to immunocompetent and immunodeficient mice.
title_full	Aerosols transmit prions to immunocompetent and immunodeficient mice.
title_fullStr	Aerosols transmit prions to immunocompetent and immunodeficient mice.
title_full_unstemmed	Aerosols transmit prions to immunocompetent and immunodeficient mice.
title_sort	aerosols transmit prions to immunocompetent and immunodeficient mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/44a0f9c403d646aa858e3bdebcca0adf
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Aerosols transmit prions to immunocompetent and immunodeficient mice.

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