Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality

The relationship between structural and physicochemical properties and antioxidant activity of peptides from amaranth 11S-globulin was studied. Peptides AWEEREQGSR, TEVWDSNEQ, IYIEQGNGITGM and YLAGKPQQEH had the greatest in vitro activity (ORAC, HORAC). GDRFQDQHQ, HVIKPPSRA and KFNRPETT were the mos...

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Autores principales:	Susan García Fillería, Agustina Estefania Nardo, Margot Paulino, Valeria Tironi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Amaranth peptides Antioxidant activity Physico-chemical properties Structures Gastrointestinal digestion Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/44a16b8ee11e429d9e06c4d5c2357f7e
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spelling	oai:doaj.org-article:44a16b8ee11e429d9e06c4d5c2357f7e2021-11-30T04:17:46ZPeptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality2666-566210.1016/j.fochms.2021.100053https://doaj.org/article/44a16b8ee11e429d9e06c4d5c2357f7e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666566221000447https://doaj.org/toc/2666-5662The relationship between structural and physicochemical properties and antioxidant activity of peptides from amaranth 11S-globulin was studied. Peptides AWEEREQGSR, TEVWDSNEQ, IYIEQGNGITGM and YLAGKPQQEH had the greatest in vitro activity (ORAC, HORAC). GDRFQDQHQ, HVIKPPSRA and KFNRPETT were the most active ones against Cu+2/H2O2-induced-LDL oxidation. In a cellular system (H2O2-induced-Caco2-TC7), TEVWDSNEQ, IYIEQGNGITGM, GDRFQDQHQ, LAGKPQQEHSGEHQ and KFNRPETT were the most effective in decreasing ROS, while the effects on SOD, GPx, and GSH were variable. To understand the structure–antioxidant activity relationships, the content of aromatic and acidic amino acids, the degree of hydrophobicity and the charge distribution on the accessible surface of peptides structures obtained by molecular dynamics were analysed. The low correlation between in vitro, ex vivo and cellular activities could be explained by the influence of physicochemical and structural properties on the interaction with complex systems (LDL/cells), peptide modifications and/or mechanisms other than direct ROS inhibition in the cells.Susan García FilleríaAgustina Estefania NardoMargot PaulinoValeria TironiElsevierarticleAmaranth peptidesAntioxidant activityPhysico-chemical propertiesStructuresGastrointestinal digestionNutrition. Foods and food supplyTX341-641ENFood Chemistry: Molecular Sciences, Vol 3, Iss , Pp 100053- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amaranth peptides Antioxidant activity Physico-chemical properties Structures Gastrointestinal digestion Nutrition. Foods and food supply TX341-641
spellingShingle	Amaranth peptides Antioxidant activity Physico-chemical properties Structures Gastrointestinal digestion Nutrition. Foods and food supply TX341-641 Susan García Fillería Agustina Estefania Nardo Margot Paulino Valeria Tironi Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality
description	The relationship between structural and physicochemical properties and antioxidant activity of peptides from amaranth 11S-globulin was studied. Peptides AWEEREQGSR, TEVWDSNEQ, IYIEQGNGITGM and YLAGKPQQEH had the greatest in vitro activity (ORAC, HORAC). GDRFQDQHQ, HVIKPPSRA and KFNRPETT were the most active ones against Cu+2/H2O2-induced-LDL oxidation. In a cellular system (H2O2-induced-Caco2-TC7), TEVWDSNEQ, IYIEQGNGITGM, GDRFQDQHQ, LAGKPQQEHSGEHQ and KFNRPETT were the most effective in decreasing ROS, while the effects on SOD, GPx, and GSH were variable. To understand the structure–antioxidant activity relationships, the content of aromatic and acidic amino acids, the degree of hydrophobicity and the charge distribution on the accessible surface of peptides structures obtained by molecular dynamics were analysed. The low correlation between in vitro, ex vivo and cellular activities could be explained by the influence of physicochemical and structural properties on the interaction with complex systems (LDL/cells), peptide modifications and/or mechanisms other than direct ROS inhibition in the cells.
format	article
author	Susan García Fillería Agustina Estefania Nardo Margot Paulino Valeria Tironi
author_facet	Susan García Fillería Agustina Estefania Nardo Margot Paulino Valeria Tironi
author_sort	Susan García Fillería
title	Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality
title_short	Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality
title_full	Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality
title_fullStr	Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality
title_full_unstemmed	Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality
title_sort	peptides derived from the gastrointestinal digestion of amaranth 11s globulin: structure and antioxidant functionality
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/44a16b8ee11e429d9e06c4d5c2357f7e
work_keys_str_mv	AT susangarciafilleria peptidesderivedfromthegastrointestinaldigestionofamaranth11sglobulinstructureandantioxidantfunctionality AT agustinaestefanianardo peptidesderivedfromthegastrointestinaldigestionofamaranth11sglobulinstructureandantioxidantfunctionality AT margotpaulino peptidesderivedfromthegastrointestinaldigestionofamaranth11sglobulinstructureandantioxidantfunctionality AT valeriatironi peptidesderivedfromthegastrointestinaldigestionofamaranth11sglobulinstructureandantioxidantfunctionality
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Peptides derived from the gastrointestinal digestion of amaranth 11S globulin: Structure and antioxidant functionality

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