Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

Autosomal dominant Alzheimer's disease is thought to be caused by increased amyloidogenic APP processing. Mattson et al.show that association between brain Aβ and cerobrospinal fluid Aβ40 levels is stronger in APOE ɛ4 negative people, suggesting that increased processing may also underlie spora...

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Autores principales:	Niklas Mattsson, Philip S. Insel, Sebastian Palmqvist, Erik Stomrud, Danielle van Westen, Lennart Minthon, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44a4c2bf90d84c7db136699be8a9a557
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spelling	oai:doaj.org-article:44a4c2bf90d84c7db136699be8a9a5572021-12-02T15:35:43ZIncreased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis10.1038/ncomms109182041-1723https://doaj.org/article/44a4c2bf90d84c7db136699be8a9a5572016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10918https://doaj.org/toc/2041-1723Autosomal dominant Alzheimer's disease is thought to be caused by increased amyloidogenic APP processing. Mattson et al.show that association between brain Aβ and cerobrospinal fluid Aβ40 levels is stronger in APOE ɛ4 negative people, suggesting that increased processing may also underlie sporadic disease.Niklas MattssonPhilip S. InselSebastian PalmqvistErik StomrudDanielle van WestenLennart MinthonHenrik ZetterbergKaj BlennowOskar HanssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niklas Mattsson Philip S. Insel Sebastian Palmqvist Erik Stomrud Danielle van Westen Lennart Minthon Henrik Zetterberg Kaj Blennow Oskar Hansson Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
description	Autosomal dominant Alzheimer's disease is thought to be caused by increased amyloidogenic APP processing. Mattson et al.show that association between brain Aβ and cerobrospinal fluid Aβ40 levels is stronger in APOE ɛ4 negative people, suggesting that increased processing may also underlie sporadic disease.
format	article
author	Niklas Mattsson Philip S. Insel Sebastian Palmqvist Erik Stomrud Danielle van Westen Lennart Minthon Henrik Zetterberg Kaj Blennow Oskar Hansson
author_facet	Niklas Mattsson Philip S. Insel Sebastian Palmqvist Erik Stomrud Danielle van Westen Lennart Minthon Henrik Zetterberg Kaj Blennow Oskar Hansson
author_sort	Niklas Mattsson
title	Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
title_short	Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
title_full	Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
title_fullStr	Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
title_full_unstemmed	Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis
title_sort	increased amyloidogenic app processing in apoe ɛ4-negative individuals with cerebral β-amyloidosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/44a4c2bf90d84c7db136699be8a9a557
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Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

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