A new computational tool for the phenomenological analysis of multipassage tumor growth curves.

Multipassage experiments are performed by subcutaneous implantation in lab animals (usually mice) of a small number of cells from selected human lines. Tumor cells are then passaged from one mouse to another by harvesting them from a growing tumor and implanting them into other healthy animals. This...

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Autores principales:	Antonio S Gliozzi, Caterina Guiot, Pier Paolo Delsanto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44a7969066df451b843974b487858a50
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spelling	oai:doaj.org-article:44a7969066df451b843974b487858a502021-11-25T06:23:01ZA new computational tool for the phenomenological analysis of multipassage tumor growth curves.1932-620310.1371/journal.pone.0005358https://doaj.org/article/44a7969066df451b843974b487858a502009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19396358/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Multipassage experiments are performed by subcutaneous implantation in lab animals (usually mice) of a small number of cells from selected human lines. Tumor cells are then passaged from one mouse to another by harvesting them from a growing tumor and implanting them into other healthy animals. This procedure may be extremely useful to investigate the various mechanisms involved in the long term evolution of tumoral growth. It has been observed by several researchers that, contrary to what happens in in vitro experiments, there is a significant growth acceleration at each new passage. This result is explained by a new method of analysis, based on the Phenomenological Universalities approach. It is found that, by means of a simple rescaling of time, it is possible to collapse all the growth curves, corresponding to the successive passages, into a single curve, belonging to the Universality Class U2. Possible applications are proposed and the need of further experimental evidence is discussed.Antonio S GliozziCaterina GuiotPier Paolo DelsantoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 4, p e5358 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio S Gliozzi Caterina Guiot Pier Paolo Delsanto A new computational tool for the phenomenological analysis of multipassage tumor growth curves.
description	Multipassage experiments are performed by subcutaneous implantation in lab animals (usually mice) of a small number of cells from selected human lines. Tumor cells are then passaged from one mouse to another by harvesting them from a growing tumor and implanting them into other healthy animals. This procedure may be extremely useful to investigate the various mechanisms involved in the long term evolution of tumoral growth. It has been observed by several researchers that, contrary to what happens in in vitro experiments, there is a significant growth acceleration at each new passage. This result is explained by a new method of analysis, based on the Phenomenological Universalities approach. It is found that, by means of a simple rescaling of time, it is possible to collapse all the growth curves, corresponding to the successive passages, into a single curve, belonging to the Universality Class U2. Possible applications are proposed and the need of further experimental evidence is discussed.
format	article
author	Antonio S Gliozzi Caterina Guiot Pier Paolo Delsanto
author_facet	Antonio S Gliozzi Caterina Guiot Pier Paolo Delsanto
author_sort	Antonio S Gliozzi
title	A new computational tool for the phenomenological analysis of multipassage tumor growth curves.
title_short	A new computational tool for the phenomenological analysis of multipassage tumor growth curves.
title_full	A new computational tool for the phenomenological analysis of multipassage tumor growth curves.
title_fullStr	A new computational tool for the phenomenological analysis of multipassage tumor growth curves.
title_full_unstemmed	A new computational tool for the phenomenological analysis of multipassage tumor growth curves.
title_sort	new computational tool for the phenomenological analysis of multipassage tumor growth curves.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/44a7969066df451b843974b487858a50
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A new computational tool for the phenomenological analysis of multipassage tumor growth curves.

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