HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.

Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA dive...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joaquín Zúñiga, Neng Yu, Rodrigo Barquera, Sharon Alosco, Marina Ohashi, Tatiana Lebedeva, Víctor Acuña-Alonzo, María Yunis, Julio Granados-Montiel, Alfredo Cruz-Lagunas, Gilberto Vargas-Alarcón, Tatiana S Rodríguez-Reyna, Marcelo Fernandez-Viña, Julio Granados, Edmond J Yunis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44a9888bd46343bd8c1e6f50a3fa3f1a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:44a9888bd46343bd8c1e6f50a3fa3f1a
record_format	dspace
spelling	oai:doaj.org-article:44a9888bd46343bd8c1e6f50a3fa3f1a2021-11-18T08:54:04ZHLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.1932-620310.1371/journal.pone.0074442https://doaj.org/article/44a9888bd46343bd8c1e6f50a3fa3f1a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086347/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA diversity in Mexican admixed individuals. We studied the polymorphism of MHC class I (HLA-A, -B, -C), and class II (HLA-DRB1, -DQB1) genes using high-resolution sequence based typing (SBT) method and we structured the blocks and conserved extended haplotypes (CEHs) in 234 non-related admixed Mexican individuals (468 haplotypes) by a maximum likelihood method. We found that HLA blocks and CEHs are primarily from Amerindian and Caucasian origin, with smaller participation of African and recent Asian ancestry, demonstrating a great diversity of HLA blocks and CEHs in Mexicans from the central area of Mexico. We also analyzed the degree of admixture in this group using short tandem repeats (STRs) and HLA-B that correlated with the frequency of most probable ancestral HLA-C/-B and -DRB1/-DQB1 blocks and CEHs. Our results contribute to the analysis of the diversity and ancestral contribution of HLA class I and HLA class II alleles and haplotypes of Mexican admixed individuals from Mexico City. This work will help as a reference to improve future studies in Mexicans regarding allotransplantation, immune responses and disease associations.Joaquín ZúñigaNeng YuRodrigo BarqueraSharon AloscoMarina OhashiTatiana LebedevaVíctor Acuña-AlonzoMaría YunisJulio Granados-MontielAlfredo Cruz-LagunasGilberto Vargas-AlarcónTatiana S Rodríguez-ReynaMarcelo Fernandez-ViñaJulio GranadosEdmond J YunisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74442 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joaquín Zúñiga Neng Yu Rodrigo Barquera Sharon Alosco Marina Ohashi Tatiana Lebedeva Víctor Acuña-Alonzo María Yunis Julio Granados-Montiel Alfredo Cruz-Lagunas Gilberto Vargas-Alarcón Tatiana S Rodríguez-Reyna Marcelo Fernandez-Viña Julio Granados Edmond J Yunis HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.
description	Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA diversity in Mexican admixed individuals. We studied the polymorphism of MHC class I (HLA-A, -B, -C), and class II (HLA-DRB1, -DQB1) genes using high-resolution sequence based typing (SBT) method and we structured the blocks and conserved extended haplotypes (CEHs) in 234 non-related admixed Mexican individuals (468 haplotypes) by a maximum likelihood method. We found that HLA blocks and CEHs are primarily from Amerindian and Caucasian origin, with smaller participation of African and recent Asian ancestry, demonstrating a great diversity of HLA blocks and CEHs in Mexicans from the central area of Mexico. We also analyzed the degree of admixture in this group using short tandem repeats (STRs) and HLA-B that correlated with the frequency of most probable ancestral HLA-C/-B and -DRB1/-DQB1 blocks and CEHs. Our results contribute to the analysis of the diversity and ancestral contribution of HLA class I and HLA class II alleles and haplotypes of Mexican admixed individuals from Mexico City. This work will help as a reference to improve future studies in Mexicans regarding allotransplantation, immune responses and disease associations.
format	article
author	Joaquín Zúñiga Neng Yu Rodrigo Barquera Sharon Alosco Marina Ohashi Tatiana Lebedeva Víctor Acuña-Alonzo María Yunis Julio Granados-Montiel Alfredo Cruz-Lagunas Gilberto Vargas-Alarcón Tatiana S Rodríguez-Reyna Marcelo Fernandez-Viña Julio Granados Edmond J Yunis
author_facet	Joaquín Zúñiga Neng Yu Rodrigo Barquera Sharon Alosco Marina Ohashi Tatiana Lebedeva Víctor Acuña-Alonzo María Yunis Julio Granados-Montiel Alfredo Cruz-Lagunas Gilberto Vargas-Alarcón Tatiana S Rodríguez-Reyna Marcelo Fernandez-Viña Julio Granados Edmond J Yunis
author_sort	Joaquín Zúñiga
title	HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.
title_short	HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.
title_full	HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.
title_fullStr	HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.
title_full_unstemmed	HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.
title_sort	hla class i and class ii conserved extended haplotypes and their fragments or blocks in mexicans: implications for the study of genetic diversity in admixed populations.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/44a9888bd46343bd8c1e6f50a3fa3f1a
work_keys_str_mv	AT joaquinzuniga hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT nengyu hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT rodrigobarquera hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT sharonalosco hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT marinaohashi hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT tatianalebedeva hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT victoracunaalonzo hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT mariayunis hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT juliogranadosmontiel hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT alfredocruzlagunas hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT gilbertovargasalarcon hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT tatianasrodriguezreyna hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT marcelofernandezvina hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT juliogranados hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations AT edmondjyunis hlaclassiandclassiiconservedextendedhaplotypesandtheirfragmentsorblocksinmexicansimplicationsforthestudyofgeneticdiversityinadmixedpopulations
_version_	1718421197125844992

HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations.

Ejemplares similares