Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task

Abstract Depression-associated cognitive impairments are among the most prevalent and persistent symptoms during remission from a depressive episode and a major risk factor for relapse. Consequently, development of antidepressant drugs, which also alleviate cognitive impairments, is vital. One such...

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Autores principales:	Lena-Sophie Martis, Kristoffer Højgaard, Megan C. Holmes, Betina Elfving, Ove Wiborg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44aa64ca3011420680ee4f0ebc979d4c
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spelling	oai:doaj.org-article:44aa64ca3011420680ee4f0ebc979d4c2021-12-02T14:53:43ZVortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task10.1038/s41598-021-88462-72045-2322https://doaj.org/article/44aa64ca3011420680ee4f0ebc979d4c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88462-7https://doaj.org/toc/2045-2322Abstract Depression-associated cognitive impairments are among the most prevalent and persistent symptoms during remission from a depressive episode and a major risk factor for relapse. Consequently, development of antidepressant drugs, which also alleviate cognitive impairments, is vital. One such potential antidepressant is vortioxetine that has been postulated to exhibit both antidepressant and pro-cognitive effects. Hence, we tested vortioxetine for combined antidepressant and pro-cognitive effects in male Long-Evans rats exposed to the chronic mild stress (CMS) paradigm. This well-established CMS paradigm evokes cognitive deficits in addition to anhedonia, a core symptom of depression. Learning and memory performance was assessed in the translational touchscreen version of the paired-associates learning task. To identify the mechanistic underpinning of the neurobehavioural results, transcriptional profiling of genes involved in the stress response, neuronal plasticity and genes of broad relevance in neuropsychiatric pathologies were assessed. Vortioxetine substantially relieved the anhedonic-like state in the CMS rats and promoted acquisition of the cognitive test independent of hedonic phenotype, potentially due to an altered cognitive strategy. Minor alterations in gene expression profiling in prefrontal cortex and hippocampus were found. In summary, our findings suggest that vortioxetine exhibits an antidepressant effect as well as behavioural changes in a translational learning task.Lena-Sophie MartisKristoffer HøjgaardMegan C. HolmesBetina ElfvingOve WiborgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lena-Sophie Martis Kristoffer Højgaard Megan C. Holmes Betina Elfving Ove Wiborg Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
description	Abstract Depression-associated cognitive impairments are among the most prevalent and persistent symptoms during remission from a depressive episode and a major risk factor for relapse. Consequently, development of antidepressant drugs, which also alleviate cognitive impairments, is vital. One such potential antidepressant is vortioxetine that has been postulated to exhibit both antidepressant and pro-cognitive effects. Hence, we tested vortioxetine for combined antidepressant and pro-cognitive effects in male Long-Evans rats exposed to the chronic mild stress (CMS) paradigm. This well-established CMS paradigm evokes cognitive deficits in addition to anhedonia, a core symptom of depression. Learning and memory performance was assessed in the translational touchscreen version of the paired-associates learning task. To identify the mechanistic underpinning of the neurobehavioural results, transcriptional profiling of genes involved in the stress response, neuronal plasticity and genes of broad relevance in neuropsychiatric pathologies were assessed. Vortioxetine substantially relieved the anhedonic-like state in the CMS rats and promoted acquisition of the cognitive test independent of hedonic phenotype, potentially due to an altered cognitive strategy. Minor alterations in gene expression profiling in prefrontal cortex and hippocampus were found. In summary, our findings suggest that vortioxetine exhibits an antidepressant effect as well as behavioural changes in a translational learning task.
format	article
author	Lena-Sophie Martis Kristoffer Højgaard Megan C. Holmes Betina Elfving Ove Wiborg
author_facet	Lena-Sophie Martis Kristoffer Højgaard Megan C. Holmes Betina Elfving Ove Wiborg
author_sort	Lena-Sophie Martis
title	Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
title_short	Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
title_full	Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
title_fullStr	Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
title_full_unstemmed	Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
title_sort	vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44aa64ca3011420680ee4f0ebc979d4c
work_keys_str_mv	AT lenasophiemartis vortioxetineamelioratesanhedoniclikebehaviourandpromotesstrategiccognitiveperformanceinarodenttouchscreentask AT kristofferhøjgaard vortioxetineamelioratesanhedoniclikebehaviourandpromotesstrategiccognitiveperformanceinarodenttouchscreentask AT megancholmes vortioxetineamelioratesanhedoniclikebehaviourandpromotesstrategiccognitiveperformanceinarodenttouchscreentask AT betinaelfving vortioxetineamelioratesanhedoniclikebehaviourandpromotesstrategiccognitiveperformanceinarodenttouchscreentask AT ovewiborg vortioxetineamelioratesanhedoniclikebehaviourandpromotesstrategiccognitiveperformanceinarodenttouchscreentask
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Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task

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