Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behaviour...

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Autores principales:	Ki Kim, Xin Wang, Emeline Ragonnaud, Monica Bodogai, Tomer Illouz, Marisa DeLuca, Ross A. McDevitt, Fedor Gusev, Eitan Okun, Evgeny Rogaev, Arya Biragyn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44ad602eff5f455e94eb988bbdc2dcdc
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spelling	oai:doaj.org-article:44ad602eff5f455e94eb988bbdc2dcdc2021-12-02T14:25:16ZTherapeutic B-cell depletion reverses progression of Alzheimer’s disease10.1038/s41467-021-22479-42041-1723https://doaj.org/article/44ad602eff5f455e94eb988bbdc2dcdc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22479-4https://doaj.org/toc/2041-1723Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behavioural manifestations of the disease.Ki KimXin WangEmeline RagonnaudMonica BodogaiTomer IllouzMarisa DeLucaRoss A. McDevittFedor GusevEitan OkunEvgeny RogaevArya BiragynNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ki Kim Xin Wang Emeline Ragonnaud Monica Bodogai Tomer Illouz Marisa DeLuca Ross A. McDevitt Fedor Gusev Eitan Okun Evgeny Rogaev Arya Biragyn Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
description	Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behavioural manifestations of the disease.
format	article
author	Ki Kim Xin Wang Emeline Ragonnaud Monica Bodogai Tomer Illouz Marisa DeLuca Ross A. McDevitt Fedor Gusev Eitan Okun Evgeny Rogaev Arya Biragyn
author_facet	Ki Kim Xin Wang Emeline Ragonnaud Monica Bodogai Tomer Illouz Marisa DeLuca Ross A. McDevitt Fedor Gusev Eitan Okun Evgeny Rogaev Arya Biragyn
author_sort	Ki Kim
title	Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_short	Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_full	Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_fullStr	Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_full_unstemmed	Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_sort	therapeutic b-cell depletion reverses progression of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44ad602eff5f455e94eb988bbdc2dcdc
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Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

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