Predicting the taxonomic and environmental sources of integron gene cassettes using structural and sequence homology of attC sites

Ghaly et al. use cassette recombination sites to predict the origins of antibiotic resistance cassettes spread by mobile integrons. They find that more than a quarter of all resistance cassettes have recombination sites that are structurally conserved among one of three taxa (Xanthomonadales, Spiroc...

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Autores principales: Timothy M. Ghaly, Sasha G. Tetu, Michael R. Gillings
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/44ae82c6ec62489e911372a9f7f6b3f4
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Sumario:Ghaly et al. use cassette recombination sites to predict the origins of antibiotic resistance cassettes spread by mobile integrons. They find that more than a quarter of all resistance cassettes have recombination sites that are structurally conserved among one of three taxa (Xanthomonadales, Spirochaetes and Vibrionales).