In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model

Aim: In this study, we aimed to evaluate soft tissue generated by periosteal distraction. Background: Management of soft tissue defects represents a challenge in dentistry. Previous periosteal distraction studies documented partial fill of the distraction space with newly-generated bone and fibrous...

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Autor principal:	Osama Zakaria
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Soft tissue Augmentation Regeneration Periosteal distraction Medicine R Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/44b1cc865ffe4ae886fc9ba68e9e9af1
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spelling	oai:doaj.org-article:44b1cc865ffe4ae886fc9ba68e9e9af12021-11-10T04:19:18ZIn situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model1013-905210.1016/j.sdentj.2020.06.001https://doaj.org/article/44b1cc865ffe4ae886fc9ba68e9e9af12021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1013905220307628https://doaj.org/toc/1013-9052Aim: In this study, we aimed to evaluate soft tissue generated by periosteal distraction. Background: Management of soft tissue defects represents a challenge in dentistry. Previous periosteal distraction studies documented partial fill of the distraction space with newly-generated bone and fibrous connective tissue. Material and methods: Titanium meshes were inserted in subperiosteal tunnels in the calvaria of 20 rats through coronal incision. The devices were immediately activated after insertion by elevation of one side at 1 mm/day for 3 days. Rats were then divided into two groups (n = 10). Animals were sacrificed after 2 weeks (Group 1) and after 4 weeks (Group 2). Distraction sites specimens were embedded in paraffin and analyzed histologically and histomorphometrically. Results: In both groups, new periosteum was regenerated and covered the original bone surface in the distraction site. Distraction spaces showed a predomination of hyper-vascularized connective tissue and little new bone formation near to the stable end of the device. The 4-week findings showed more organized collagen fibers with less vascularity compared to the 2-week findings. Conclusion: The periosteal distraction technique can effectively regenerate connective tissue. It may open a new modality in the guided tissue regeneration for soft tissue augmentation.Osama ZakariaElsevierarticleSoft tissueAugmentationRegenerationPeriosteal distractionMedicineRDentistryRK1-715ENSaudi Dental Journal, Vol 33, Iss 7, Pp 587-594 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Soft tissue Augmentation Regeneration Periosteal distraction Medicine R Dentistry RK1-715
spellingShingle	Soft tissue Augmentation Regeneration Periosteal distraction Medicine R Dentistry RK1-715 Osama Zakaria In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
description	Aim: In this study, we aimed to evaluate soft tissue generated by periosteal distraction. Background: Management of soft tissue defects represents a challenge in dentistry. Previous periosteal distraction studies documented partial fill of the distraction space with newly-generated bone and fibrous connective tissue. Material and methods: Titanium meshes were inserted in subperiosteal tunnels in the calvaria of 20 rats through coronal incision. The devices were immediately activated after insertion by elevation of one side at 1 mm/day for 3 days. Rats were then divided into two groups (n = 10). Animals were sacrificed after 2 weeks (Group 1) and after 4 weeks (Group 2). Distraction sites specimens were embedded in paraffin and analyzed histologically and histomorphometrically. Results: In both groups, new periosteum was regenerated and covered the original bone surface in the distraction site. Distraction spaces showed a predomination of hyper-vascularized connective tissue and little new bone formation near to the stable end of the device. The 4-week findings showed more organized collagen fibers with less vascularity compared to the 2-week findings. Conclusion: The periosteal distraction technique can effectively regenerate connective tissue. It may open a new modality in the guided tissue regeneration for soft tissue augmentation.
format	article
author	Osama Zakaria
author_facet	Osama Zakaria
author_sort	Osama Zakaria
title	In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
title_short	In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
title_full	In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
title_fullStr	In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
title_full_unstemmed	In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
title_sort	in situ soft tissue regeneration using periosteal distraction: a preliminary study in the rat calvarial model
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/44b1cc865ffe4ae886fc9ba68e9e9af1
work_keys_str_mv	AT osamazakaria insitusofttissueregenerationusingperiostealdistractionapreliminarystudyintheratcalvarialmodel
_version_	1718440643317989376

In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model

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