Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties t...

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Autores principales: Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F. B. Räder, William J. Polacheck, Horst Kessler, Lydia Sorokin, Britta Trappmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/44b2977179d84acea256312132cf8fe7
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Sumario:Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.