Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties t...

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Autores principales:	Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F. B. Räder, William J. Polacheck, Horst Kessler, Lydia Sorokin, Britta Trappmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44b2977179d84acea256312132cf8fe7
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spelling	oai:doaj.org-article:44b2977179d84acea256312132cf8fe72021-12-02T17:34:29ZSynthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting10.1038/s41467-021-23644-52041-1723https://doaj.org/article/44b2977179d84acea256312132cf8fe72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23644-5https://doaj.org/toc/2041-1723Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.Jifeng LiuHongyan LongDagmar ZeuschnerAndreas F. B. RäderWilliam J. PolacheckHorst KesslerLydia SorokinBritta TrappmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jifeng Liu Hongyan Long Dagmar Zeuschner Andreas F. B. Räder William J. Polacheck Horst Kessler Lydia Sorokin Britta Trappmann Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
description	Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.
format	article
author	Jifeng Liu Hongyan Long Dagmar Zeuschner Andreas F. B. Räder William J. Polacheck Horst Kessler Lydia Sorokin Britta Trappmann
author_facet	Jifeng Liu Hongyan Long Dagmar Zeuschner Andreas F. B. Räder William J. Polacheck Horst Kessler Lydia Sorokin Britta Trappmann
author_sort	Jifeng Liu
title	Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
title_short	Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
title_full	Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
title_fullStr	Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
title_full_unstemmed	Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
title_sort	synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44b2977179d84acea256312132cf8fe7
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Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

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