Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients

Abstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acqui...

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Autores principales:	Rodolfo Solís-Vivanco, Alejandra Mondragón-Maya, Francisco Reyes-Madrigal, Camilo de la Fuente-Sandoval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/44b3c2c2ed4448aaa08e7447ae69e7ae
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spelling	oai:doaj.org-article:44b3c2c2ed4448aaa08e7447ae69e7ae2021-12-02T13:20:09ZImpairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients10.1038/s41537-021-00146-32334-265Xhttps://doaj.org/article/44b3c2c2ed4448aaa08e7447ae69e7ae2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00146-3https://doaj.org/toc/2334-265XAbstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms.Rodolfo Solís-VivancoAlejandra Mondragón-MayaFrancisco Reyes-MadrigalCamilo de la Fuente-SandovalNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Rodolfo Solís-Vivanco Alejandra Mondragón-Maya Francisco Reyes-Madrigal Camilo de la Fuente-Sandoval Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
description	Abstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms.
format	article
author	Rodolfo Solís-Vivanco Alejandra Mondragón-Maya Francisco Reyes-Madrigal Camilo de la Fuente-Sandoval
author_facet	Rodolfo Solís-Vivanco Alejandra Mondragón-Maya Francisco Reyes-Madrigal Camilo de la Fuente-Sandoval
author_sort	Rodolfo Solís-Vivanco
title	Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
title_short	Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
title_full	Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
title_fullStr	Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
title_full_unstemmed	Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
title_sort	impairment of novelty-related theta oscillations and p3a in never medicated first-episode psychosis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44b3c2c2ed4448aaa08e7447ae69e7ae
work_keys_str_mv	AT rodolfosolisvivanco impairmentofnoveltyrelatedthetaoscillationsandp3ainnevermedicatedfirstepisodepsychosispatients AT alejandramondragonmaya impairmentofnoveltyrelatedthetaoscillationsandp3ainnevermedicatedfirstepisodepsychosispatients AT franciscoreyesmadrigal impairmentofnoveltyrelatedthetaoscillationsandp3ainnevermedicatedfirstepisodepsychosispatients AT camilodelafuentesandoval impairmentofnoveltyrelatedthetaoscillationsandp3ainnevermedicatedfirstepisodepsychosispatients
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Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients

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