Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

Chronic manifestations of Chagas disease present as disabling and life-threatening conditions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying <i>Trypanosoma cruzi’s</i> infection and...

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Autores principales:	Germán J. Medina-Rincón, Sebastián Gallo-Bernal, Paula A. Jiménez, Lissa Cruz-Saavedra, Juan David Ramírez, María Juliana Rodríguez, Ramón Medina-Mur, Gustavo Díaz-Nassif, María Daniela Valderrama-Achury, Héctor M. Medina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Chagas disease <i>Trypanosoma cruzi</i> vector-borne disease heart failure cardiomyopathy achalasia Medicine R
Acceso en línea:	https://doaj.org/article/44b9bb67bb2e46339a6e05e562582b4e
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spelling	oai:doaj.org-article:44b9bb67bb2e46339a6e05e562582b4e2021-11-25T18:38:41ZMolecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review10.3390/pathogens101114932076-0817https://doaj.org/article/44b9bb67bb2e46339a6e05e562582b4e2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1493https://doaj.org/toc/2076-0817Chronic manifestations of Chagas disease present as disabling and life-threatening conditions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying <i>Trypanosoma cruzi’s</i> infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particularly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.Germán J. Medina-RincónSebastián Gallo-BernalPaula A. JiménezLissa Cruz-SaavedraJuan David RamírezMaría Juliana RodríguezRamón Medina-MurGustavo Díaz-NassifMaría Daniela Valderrama-AchuryHéctor M. MedinaMDPI AGarticleChagas disease<i>Trypanosoma cruzi</i>vector-borne diseaseheart failurecardiomyopathyachalasiaMedicineRENPathogens, Vol 10, Iss 1493, p 1493 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chagas disease <i>Trypanosoma cruzi</i> vector-borne disease heart failure cardiomyopathy achalasia Medicine R
spellingShingle	Chagas disease <i>Trypanosoma cruzi</i> vector-borne disease heart failure cardiomyopathy achalasia Medicine R Germán J. Medina-Rincón Sebastián Gallo-Bernal Paula A. Jiménez Lissa Cruz-Saavedra Juan David Ramírez María Juliana Rodríguez Ramón Medina-Mur Gustavo Díaz-Nassif María Daniela Valderrama-Achury Héctor M. Medina Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review
description	Chronic manifestations of Chagas disease present as disabling and life-threatening conditions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying <i>Trypanosoma cruzi’s</i> infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particularly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.
format	article
author	Germán J. Medina-Rincón Sebastián Gallo-Bernal Paula A. Jiménez Lissa Cruz-Saavedra Juan David Ramírez María Juliana Rodríguez Ramón Medina-Mur Gustavo Díaz-Nassif María Daniela Valderrama-Achury Héctor M. Medina
author_facet	Germán J. Medina-Rincón Sebastián Gallo-Bernal Paula A. Jiménez Lissa Cruz-Saavedra Juan David Ramírez María Juliana Rodríguez Ramón Medina-Mur Gustavo Díaz-Nassif María Daniela Valderrama-Achury Héctor M. Medina
author_sort	Germán J. Medina-Rincón
title	Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review
title_short	Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review
title_full	Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review
title_fullStr	Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review
title_full_unstemmed	Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review
title_sort	molecular and clinical aspects of chronic manifestations in chagas disease: a state-of-the-art review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/44b9bb67bb2e46339a6e05e562582b4e
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Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

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