Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China

Background: Hepatitis B surface antigen (HBsAg) is widely used in hepatitis B screening, and HBsAg seroclearance indicates hepatitis B eradication. Few studies have explored the incidence of and determinants for spontaneous seroclearance using a long-term follow-up cohort study. Our research aimed t...

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Autores principales:	Haiyang Hu, Yangfan Shen, Ming Hu, Yang Zheng, Kaijin Xu, Lanjuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatitis B surface antigen hepatitis B virus natural history incidence rate influencing factor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/44ba3ebc97a1412e89cac249309713ff
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spelling	oai:doaj.org-article:44ba3ebc97a1412e89cac249309713ff2021-11-18T07:26:05ZIncidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China2296-858X10.3389/fmed.2021.717667https://doaj.org/article/44ba3ebc97a1412e89cac249309713ff2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.717667/fullhttps://doaj.org/toc/2296-858XBackground: Hepatitis B surface antigen (HBsAg) is widely used in hepatitis B screening, and HBsAg seroclearance indicates hepatitis B eradication. Few studies have explored the incidence of and determinants for spontaneous seroclearance using a long-term follow-up cohort study. Our research aimed to examine the incidence of and influencing factors for hepatitis B virus infection and spontaneous clearance of HBsAg from a large-scale cohort in China.Methods: A total of 151,926 resident individuals in Tongxiang underwent HBsAg screening at least thrice in a 7-year period. Serum samples collected at baseline and follow-up examinations were tested for HBsAg. Cox proportional hazard models were used to analyze determinants of HBsAg seroclearance and persistent HBsAg presence.Results: Among the 151,926 participants, new hepatitis B infections occurred in 4,497 participants, yielding an incidence rate of 571.38 per 100,000 person-years. The incidence rate for males was higher than that for females. In the multivariate Cox regression analysis, female gender, alcohol drinking history, hepatitis family history and middle-age group were predictors for persistent positive HBsAg status.Conclusions: The incidence rate of new hepatitis B infections was 571.38 per 100,000 person-years. Male and aged people in this community cohort have a higher infection rate. Alcohol drinking and hepatitis family history were risk factor leading to chronic infection. Female and middle-aged people were prone to persistent positive HBsAg status.Haiyang HuYangfan ShenMing HuYang ZhengKaijin XuLanjuan LiFrontiers Media S.A.articlehepatitis B surface antigenhepatitis B virusnatural historyincidence rateinfluencing factorMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis B surface antigen hepatitis B virus natural history incidence rate influencing factor Medicine (General) R5-920
spellingShingle	hepatitis B surface antigen hepatitis B virus natural history incidence rate influencing factor Medicine (General) R5-920 Haiyang Hu Yangfan Shen Ming Hu Yang Zheng Kaijin Xu Lanjuan Li Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China
description	Background: Hepatitis B surface antigen (HBsAg) is widely used in hepatitis B screening, and HBsAg seroclearance indicates hepatitis B eradication. Few studies have explored the incidence of and determinants for spontaneous seroclearance using a long-term follow-up cohort study. Our research aimed to examine the incidence of and influencing factors for hepatitis B virus infection and spontaneous clearance of HBsAg from a large-scale cohort in China.Methods: A total of 151,926 resident individuals in Tongxiang underwent HBsAg screening at least thrice in a 7-year period. Serum samples collected at baseline and follow-up examinations were tested for HBsAg. Cox proportional hazard models were used to analyze determinants of HBsAg seroclearance and persistent HBsAg presence.Results: Among the 151,926 participants, new hepatitis B infections occurred in 4,497 participants, yielding an incidence rate of 571.38 per 100,000 person-years. The incidence rate for males was higher than that for females. In the multivariate Cox regression analysis, female gender, alcohol drinking history, hepatitis family history and middle-age group were predictors for persistent positive HBsAg status.Conclusions: The incidence rate of new hepatitis B infections was 571.38 per 100,000 person-years. Male and aged people in this community cohort have a higher infection rate. Alcohol drinking and hepatitis family history were risk factor leading to chronic infection. Female and middle-aged people were prone to persistent positive HBsAg status.
format	article
author	Haiyang Hu Yangfan Shen Ming Hu Yang Zheng Kaijin Xu Lanjuan Li
author_facet	Haiyang Hu Yangfan Shen Ming Hu Yang Zheng Kaijin Xu Lanjuan Li
author_sort	Haiyang Hu
title	Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China
title_short	Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China
title_full	Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China
title_fullStr	Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China
title_full_unstemmed	Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China
title_sort	incidence and influencing factors of new hepatitis b infections and spontaneous clearance: a large-scale, community-based study in china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/44ba3ebc97a1412e89cac249309713ff
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_version_	1718423469895450624

Incidence and Influencing Factors of New Hepatitis B Infections and Spontaneous Clearance: A Large-Scale, Community-Based Study in China

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