Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor

Xiaoyu Li, Meiying Wu, Limin Pan, Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People’s Republic of China Abstract: To overcome the drawback of drug non-selectivity in tr...

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Autores principales:	Li X, Wu M, Pan L, Shi J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	mesoporous silica nanoparticles drug delivery tumor vasculatures targeting antiangiogenic agent Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/44bb394f84e6437da230883706d08ad3
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spelling	oai:doaj.org-article:44bb394f84e6437da230883706d08ad32021-12-02T00:54:30ZTumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor1178-2013https://doaj.org/article/44bb394f84e6437da230883706d08ad32015-12-01T00:00:00Zhttps://www.dovepress.com/tumor-vascular-targeted-co-delivery-of-anti-angiogenesis-and-chemother-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoyu Li, Meiying Wu, Limin Pan, Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People’s Republic of China Abstract: To overcome the drawback of drug non-selectivity in traditional chemotherapy, the construction of multifunctional targeting drug delivery systems is one of the most effective and prevailing approaches. The intratumoral anti-angiogenesis and the tumor cell-killing are two basic approaches in fighting tumors. Herein we report a novel tumor vascular-targeting multidrug delivery system using mesoporous silica nanoparticles as carrier to co-load an antiangiogenic agent (combretastatin A4) and a chemotherapeutic drug (doxorubicin) and conjugate with targeting molecules (iRGD peptide) for combined anti-angiogenesis and chemotherapy. Such a dual-loaded drug delivery system is capable of delivering the two agents at tumor vasculature and then within tumors through a differentiated drug release strategy, which consequently results in greatly improved antitumor efficacy at a very low doxorubicin dose of 1.5 mg/kg. The fast release of the antiangiogenic agent at tumor vasculatures led to the disruption of vascular structure and had a synergetic effect with the chemotherapeutic drug slowly released in the following delivery of chemotherapeutic drug into tumors. Keywords: mesoporous silica nanoparticles, drug delivery, tumor vasculatures targeting, antiangiogenic agentLi XWu MPan LShi JDove Medical Pressarticlemesoporous silica nanoparticlesdrug deliverytumor vasculatures targetingantiangiogenic agentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 93-105 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica nanoparticles drug delivery tumor vasculatures targeting antiangiogenic agent Medicine (General) R5-920
spellingShingle	mesoporous silica nanoparticles drug delivery tumor vasculatures targeting antiangiogenic agent Medicine (General) R5-920 Li X Wu M Pan L Shi J Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
description	Xiaoyu Li, Meiying Wu, Limin Pan, Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People’s Republic of China Abstract: To overcome the drawback of drug non-selectivity in traditional chemotherapy, the construction of multifunctional targeting drug delivery systems is one of the most effective and prevailing approaches. The intratumoral anti-angiogenesis and the tumor cell-killing are two basic approaches in fighting tumors. Herein we report a novel tumor vascular-targeting multidrug delivery system using mesoporous silica nanoparticles as carrier to co-load an antiangiogenic agent (combretastatin A4) and a chemotherapeutic drug (doxorubicin) and conjugate with targeting molecules (iRGD peptide) for combined anti-angiogenesis and chemotherapy. Such a dual-loaded drug delivery system is capable of delivering the two agents at tumor vasculature and then within tumors through a differentiated drug release strategy, which consequently results in greatly improved antitumor efficacy at a very low doxorubicin dose of 1.5 mg/kg. The fast release of the antiangiogenic agent at tumor vasculatures led to the disruption of vascular structure and had a synergetic effect with the chemotherapeutic drug slowly released in the following delivery of chemotherapeutic drug into tumors. Keywords: mesoporous silica nanoparticles, drug delivery, tumor vasculatures targeting, antiangiogenic agent
format	article
author	Li X Wu M Pan L Shi J
author_facet	Li X Wu M Pan L Shi J
author_sort	Li X
title	Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
title_short	Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
title_full	Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
title_fullStr	Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
title_full_unstemmed	Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
title_sort	tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/44bb394f84e6437da230883706d08ad3
work_keys_str_mv	AT lix tumorvasculartargetedcodeliveryofantiangiogenesisandchemotherapeuticagentsbymesoporoussilicananoparticlebaseddrugdeliverysystemforsynergetictherapyoftumor AT wum tumorvasculartargetedcodeliveryofantiangiogenesisandchemotherapeuticagentsbymesoporoussilicananoparticlebaseddrugdeliverysystemforsynergetictherapyoftumor AT panl tumorvasculartargetedcodeliveryofantiangiogenesisandchemotherapeuticagentsbymesoporoussilicananoparticlebaseddrugdeliverysystemforsynergetictherapyoftumor AT shij tumorvasculartargetedcodeliveryofantiangiogenesisandchemotherapeuticagentsbymesoporoussilicananoparticlebaseddrugdeliverysystemforsynergetictherapyoftumor
_version_	1718403433941172224

Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor

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