FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)

Abstract. We investigated levels of spontaneous and mitogen-induced cytokine production (IL-1β, IL-4, IL-6, IL-10 and IFNγ) by peripheral blood cells of 24 men with unstable angina (UA), including indigenous population (n = 12, Yakuts), and a group of Russian migrants to the Republic of Sakha (n = 1...

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Autores principales:	A. S. Golderova, I. N. Nikolaeva, V. E. Tarasova, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines atherosclerosis unstable angina Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/44bec16f60a5462ba4325cc8ccfde48e
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spelling	oai:doaj.org-article:44bec16f60a5462ba4325cc8ccfde48e2021-11-18T08:03:40ZFEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)1563-06252313-741X10.15789/1563-0625-2012-1-2-143-148https://doaj.org/article/44bec16f60a5462ba4325cc8ccfde48e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/316https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We investigated levels of spontaneous and mitogen-induced cytokine production (IL-1β, IL-4, IL-6, IL-10 and IFNγ) by peripheral blood cells of 24 men with unstable angina (UA), including indigenous population (n = 12, Yakuts), and a group of Russian migrants to the Republic of Sakha (n = 12). Activation of inflammatory response was revealed in the total group of patients with UA, manifesting by increase of spontaneous and induced production of the pro-inflammatory IL-1β, IL-6 cytokines, and mitogen-induced production of IFNγ. As compared with healthy individuals, spontaneous and induced production of anti-inflammatory IL-4 was decreased in UA patients, whereas the mitogen-induced production of IL-10 proved to be enhanced. Therefore, it is highly possible that a pro-atherogenic Th1-immune response is developing during UA, along with suppression of Th2-driving response. The differences revealed for different ethnic groups suggest that severity and prevalence of atherosclerotic disease, which is more common in the non-native patients, is associated with increased production of pro-inflammatory IL-1β and IL-6 cytokines.A. S. GolderovaI. N. NikolaevaV. E. TarasovaV. A. KozlovSPb RAACIarticlecytokinesatherosclerosisunstable anginaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 143-148 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines atherosclerosis unstable angina Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines atherosclerosis unstable angina Immunologic diseases. Allergy RC581-607 A. S. Golderova I. N. Nikolaeva V. E. Tarasova V. A. Kozlov FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)
description	Abstract. We investigated levels of spontaneous and mitogen-induced cytokine production (IL-1β, IL-4, IL-6, IL-10 and IFNγ) by peripheral blood cells of 24 men with unstable angina (UA), including indigenous population (n = 12, Yakuts), and a group of Russian migrants to the Republic of Sakha (n = 12). Activation of inflammatory response was revealed in the total group of patients with UA, manifesting by increase of spontaneous and induced production of the pro-inflammatory IL-1β, IL-6 cytokines, and mitogen-induced production of IFNγ. As compared with healthy individuals, spontaneous and induced production of anti-inflammatory IL-4 was decreased in UA patients, whereas the mitogen-induced production of IL-10 proved to be enhanced. Therefore, it is highly possible that a pro-atherogenic Th1-immune response is developing during UA, along with suppression of Th2-driving response. The differences revealed for different ethnic groups suggest that severity and prevalence of atherosclerotic disease, which is more common in the non-native patients, is associated with increased production of pro-inflammatory IL-1β and IL-6 cytokines.
format	article
author	A. S. Golderova I. N. Nikolaeva V. E. Tarasova V. A. Kozlov
author_facet	A. S. Golderova I. N. Nikolaeva V. E. Tarasova V. A. Kozlov
author_sort	A. S. Golderova
title	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)
title_short	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)
title_full	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)
title_fullStr	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)
title_full_unstemmed	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)
title_sort	features of cytokine production in patients with unstable angina: dependence on ethnicity in the republic of sakha (yakutia)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/44bec16f60a5462ba4325cc8ccfde48e
work_keys_str_mv	AT asgolderova featuresofcytokineproductioninpatientswithunstableanginadependenceonethnicityintherepublicofsakhayakutia AT innikolaeva featuresofcytokineproductioninpatientswithunstableanginadependenceonethnicityintherepublicofsakhayakutia AT vetarasova featuresofcytokineproductioninpatientswithunstableanginadependenceonethnicityintherepublicofsakhayakutia AT vakozlov featuresofcytokineproductioninpatientswithunstableanginadependenceonethnicityintherepublicofsakhayakutia
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FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)

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