Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31

Employing the flexible hexacarboxylate ligand of 1,3,5-triazine-2,4,6-triamine hexaacetic acid (H6TTHA) to assemble with Co(NO3)2·6H2O, we have acquired a novel coordination compound, i.e., [Co2(H2TTHA)(H2O)]n·6n(H2O) (1). The analysis of single X-ray diffraction indicated that the H2TTHA2- ligand μ...

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Autores principales:	Zhenshan Guo, Jun Zhen, Zhoujia Yao, Yemeng Wang, Chenlu Jin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/44c0950b00294a83b09b4e2aa2d34f2e
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spelling	oai:doaj.org-article:44c0950b00294a83b09b4e2aa2d34f2e2021-11-15T01:19:28ZMagnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA311687-943010.1155/2021/2621863https://doaj.org/article/44c0950b00294a83b09b4e2aa2d34f2e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2621863https://doaj.org/toc/1687-9430Employing the flexible hexacarboxylate ligand of 1,3,5-triazine-2,4,6-triamine hexaacetic acid (H6TTHA) to assemble with Co(NO3)2·6H2O, we have acquired a novel coordination compound, i.e., [Co2(H2TTHA)(H2O)]n·6n(H2O) (1). The analysis of single X-ray diffraction indicated that the H2TTHA2- ligand μ5-bridges connected the Co(II) ions into a two-dimensional layered architecture. Moreover, the magnetic property of 1 was also investigated between 2 and 300 K under 1000 Oe applied magnetic field. The novel compound’s inhibitory activity against the viability of cancer cell was determined through CCK-8 assay, and the expression of miRNA31 in liver cancer cells was detected via the real-time RT-PCR.Zhenshan GuoJun ZhenZhoujia YaoYemeng WangChenlu JinHindawi LimitedarticleChemical technologyTP1-1185ENInternational Journal of Polymer Science, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemical technology TP1-1185
spellingShingle	Chemical technology TP1-1185 Zhenshan Guo Jun Zhen Zhoujia Yao Yemeng Wang Chenlu Jin Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
description	Employing the flexible hexacarboxylate ligand of 1,3,5-triazine-2,4,6-triamine hexaacetic acid (H6TTHA) to assemble with Co(NO3)2·6H2O, we have acquired a novel coordination compound, i.e., [Co2(H2TTHA)(H2O)]n·6n(H2O) (1). The analysis of single X-ray diffraction indicated that the H2TTHA2- ligand μ5-bridges connected the Co(II) ions into a two-dimensional layered architecture. Moreover, the magnetic property of 1 was also investigated between 2 and 300 K under 1000 Oe applied magnetic field. The novel compound’s inhibitory activity against the viability of cancer cell was determined through CCK-8 assay, and the expression of miRNA31 in liver cancer cells was detected via the real-time RT-PCR.
format	article
author	Zhenshan Guo Jun Zhen Zhoujia Yao Yemeng Wang Chenlu Jin
author_facet	Zhenshan Guo Jun Zhen Zhoujia Yao Yemeng Wang Chenlu Jin
author_sort	Zhenshan Guo
title	Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
title_short	Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
title_full	Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
title_fullStr	Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
title_full_unstemmed	Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
title_sort	magnetic property and therapeutic effect of a new co(ii) complex on liver cancer by regulating the expression of mirna31
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/44c0950b00294a83b09b4e2aa2d34f2e
work_keys_str_mv	AT zhenshanguo magneticpropertyandtherapeuticeffectofanewcoiicomplexonlivercancerbyregulatingtheexpressionofmirna31 AT junzhen magneticpropertyandtherapeuticeffectofanewcoiicomplexonlivercancerbyregulatingtheexpressionofmirna31 AT zhoujiayao magneticpropertyandtherapeuticeffectofanewcoiicomplexonlivercancerbyregulatingtheexpressionofmirna31 AT yemengwang magneticpropertyandtherapeuticeffectofanewcoiicomplexonlivercancerbyregulatingtheexpressionofmirna31 AT chenlujin magneticpropertyandtherapeuticeffectofanewcoiicomplexonlivercancerbyregulatingtheexpressionofmirna31
_version_	1718428917972336640

Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31

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