Distress Analysis of Mice with Cervical Arteriovenous Fistulas

The welfare of laboratory animals is a consistent concern for researchers. Its evaluation not only fosters ethical responsibility and addresses legal requirements, but also provides a solid basis for a high quality of research. Recently, a new cervical arteriovenous model was created in mice to unde...

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Autores principales:	Wentao Xie, Rupert Palme, Clemens Schafmayer, Dietmar Zechner, Brigitte Vollmar, Eberhard Grambow
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hemodialysis access animal model distress animal welfare 3R rule Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/44cadd25a08d4c4f843df62dd86d08fb
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spelling	oai:doaj.org-article:44cadd25a08d4c4f843df62dd86d08fb2021-11-25T16:14:11ZDistress Analysis of Mice with Cervical Arteriovenous Fistulas10.3390/ani111130512076-2615https://doaj.org/article/44cadd25a08d4c4f843df62dd86d08fb2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3051https://doaj.org/toc/2076-2615The welfare of laboratory animals is a consistent concern for researchers. Its evaluation not only fosters ethical responsibility and addresses legal requirements, but also provides a solid basis for a high quality of research. Recently, a new cervical arteriovenous model was created in mice to understand the pathophysiology of arteriovenous fistula, which is the most commonly used access for hemodialysis. This study evaluates the distress caused by this new animal model. Ten male C57B6/J mice with cervical arteriovenous fistula were observed for 21 days. Non-invasive parameters, such as body weight, faecal corticosterone metabolites, burrowing activity, nesting activity and distress scores were evaluated at each time point. Six out of ten created arteriovenous fistula matured within the observation time as defined by an increased diameter. The body weight of all animals was reduced after surgery but recovered within five days. In addition, the distress score was significantly increased during the early time point but not at the late time point after arteriovenous fistula creation. Neither burrowing activity nor nesting behaviour were significantly reduced after surgical intervention. Moreover, faecal corticosterone metabolite concentrations did not significantly increase. Therefore, the cervical murine arteriovenous fistula model induced moderate distress in mice and revealed an appropriate maturation rate of the fistulas.Wentao XieRupert PalmeClemens SchafmayerDietmar ZechnerBrigitte VollmarEberhard GrambowMDPI AGarticlehemodialysis accessanimal modeldistressanimal welfare3R ruleVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3051, p 3051 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hemodialysis access animal model distress animal welfare 3R rule Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	hemodialysis access animal model distress animal welfare 3R rule Veterinary medicine SF600-1100 Zoology QL1-991 Wentao Xie Rupert Palme Clemens Schafmayer Dietmar Zechner Brigitte Vollmar Eberhard Grambow Distress Analysis of Mice with Cervical Arteriovenous Fistulas
description	The welfare of laboratory animals is a consistent concern for researchers. Its evaluation not only fosters ethical responsibility and addresses legal requirements, but also provides a solid basis for a high quality of research. Recently, a new cervical arteriovenous model was created in mice to understand the pathophysiology of arteriovenous fistula, which is the most commonly used access for hemodialysis. This study evaluates the distress caused by this new animal model. Ten male C57B6/J mice with cervical arteriovenous fistula were observed for 21 days. Non-invasive parameters, such as body weight, faecal corticosterone metabolites, burrowing activity, nesting activity and distress scores were evaluated at each time point. Six out of ten created arteriovenous fistula matured within the observation time as defined by an increased diameter. The body weight of all animals was reduced after surgery but recovered within five days. In addition, the distress score was significantly increased during the early time point but not at the late time point after arteriovenous fistula creation. Neither burrowing activity nor nesting behaviour were significantly reduced after surgical intervention. Moreover, faecal corticosterone metabolite concentrations did not significantly increase. Therefore, the cervical murine arteriovenous fistula model induced moderate distress in mice and revealed an appropriate maturation rate of the fistulas.
format	article
author	Wentao Xie Rupert Palme Clemens Schafmayer Dietmar Zechner Brigitte Vollmar Eberhard Grambow
author_facet	Wentao Xie Rupert Palme Clemens Schafmayer Dietmar Zechner Brigitte Vollmar Eberhard Grambow
author_sort	Wentao Xie
title	Distress Analysis of Mice with Cervical Arteriovenous Fistulas
title_short	Distress Analysis of Mice with Cervical Arteriovenous Fistulas
title_full	Distress Analysis of Mice with Cervical Arteriovenous Fistulas
title_fullStr	Distress Analysis of Mice with Cervical Arteriovenous Fistulas
title_full_unstemmed	Distress Analysis of Mice with Cervical Arteriovenous Fistulas
title_sort	distress analysis of mice with cervical arteriovenous fistulas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/44cadd25a08d4c4f843df62dd86d08fb
work_keys_str_mv	AT wentaoxie distressanalysisofmicewithcervicalarteriovenousfistulas AT rupertpalme distressanalysisofmicewithcervicalarteriovenousfistulas AT clemensschafmayer distressanalysisofmicewithcervicalarteriovenousfistulas AT dietmarzechner distressanalysisofmicewithcervicalarteriovenousfistulas AT brigittevollmar distressanalysisofmicewithcervicalarteriovenousfistulas AT eberhardgrambow distressanalysisofmicewithcervicalarteriovenousfistulas
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Distress Analysis of Mice with Cervical Arteriovenous Fistulas

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