Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.

The authors have previously presented a mathematical model to predict transit time of a neutrophil through an alveolar capillary segment which was modeled as an axisymmetric arc-shaped constriction settled in a cylindrical straight pipe to investigate the influence of entrance curvature of a capilla...

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Autores principales:	Atsushi Shirai, Sunao Masuda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44d0e118b26446ce933d0934f3fd3dff
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spelling	oai:doaj.org-article:44d0e118b26446ce933d0934f3fd3dff2021-11-18T07:52:39ZNumerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.1932-620310.1371/journal.pone.0059416https://doaj.org/article/44d0e118b26446ce933d0934f3fd3dff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527190/?tool=EBIhttps://doaj.org/toc/1932-6203The authors have previously presented a mathematical model to predict transit time of a neutrophil through an alveolar capillary segment which was modeled as an axisymmetric arc-shaped constriction settled in a cylindrical straight pipe to investigate the influence of entrance curvature of a capillary on passage of the cell. The axially asymmetric cross section of a capillary also influences the transit time because it requires three-dimensional deformation of a cell when it passes through the capillary and could lead to plasma leakage between the cell surface and the capillary wall. In this study, a rectangular channel was introduced, the side walls of which were moderately constricted, as a representative of axially asymmetric capillaries. Dependence of transit time of a neutrophil passing through the constriction on the constriction geometry, i.e., channel height, throat width and curvature radius of the constriction, was numerically investigated, the transit time being compared with that through the axisymmetric model. It was found that the transit time is dominated by the throat hydraulic diameter and curvature radius of the constriction and that the throat aspect ratio little affects the transit time with a certain limitation, indicating that if an appropriate curvature radius is chosen, such a rectangular channel model can be substituted for an axisymmetric capillary model having the same throat hydraulic diameter in terms of the transit time by choosing an appropriate curvature radius. Thus, microchannels fabricated by the photolithography technique, whose cross section is generally rectangular, are expected to be applicable to in vitro model experiments of neutrophil retention and passage in the alveolar capillaries.Atsushi ShiraiSunao MasudaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59416 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsushi Shirai Sunao Masuda Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
description	The authors have previously presented a mathematical model to predict transit time of a neutrophil through an alveolar capillary segment which was modeled as an axisymmetric arc-shaped constriction settled in a cylindrical straight pipe to investigate the influence of entrance curvature of a capillary on passage of the cell. The axially asymmetric cross section of a capillary also influences the transit time because it requires three-dimensional deformation of a cell when it passes through the capillary and could lead to plasma leakage between the cell surface and the capillary wall. In this study, a rectangular channel was introduced, the side walls of which were moderately constricted, as a representative of axially asymmetric capillaries. Dependence of transit time of a neutrophil passing through the constriction on the constriction geometry, i.e., channel height, throat width and curvature radius of the constriction, was numerically investigated, the transit time being compared with that through the axisymmetric model. It was found that the transit time is dominated by the throat hydraulic diameter and curvature radius of the constriction and that the throat aspect ratio little affects the transit time with a certain limitation, indicating that if an appropriate curvature radius is chosen, such a rectangular channel model can be substituted for an axisymmetric capillary model having the same throat hydraulic diameter in terms of the transit time by choosing an appropriate curvature radius. Thus, microchannels fabricated by the photolithography technique, whose cross section is generally rectangular, are expected to be applicable to in vitro model experiments of neutrophil retention and passage in the alveolar capillaries.
format	article
author	Atsushi Shirai Sunao Masuda
author_facet	Atsushi Shirai Sunao Masuda
author_sort	Atsushi Shirai
title	Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
title_short	Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
title_full	Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
title_fullStr	Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
title_full_unstemmed	Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
title_sort	numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/44d0e118b26446ce933d0934f3fd3dff
work_keys_str_mv	AT atsushishirai numericalsimulationofpassageofaneutrophilthrougharectangularchannelwithamoderateconstriction AT sunaomasuda numericalsimulationofpassageofaneutrophilthrougharectangularchannelwithamoderateconstriction
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Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.

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