Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication

Cystic lesions of the liver are a heterogeneous group of disorders with varied etiology, prevalence, and clinical manifestations. Fibropolycystic liver disease encompasses a spectrum of related liver and biliary tract lesions caused by abnormal embryologic development of the ductal plates. These dis...

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Autores principales:	Elona Shehi, Ked Fortuzi, Haider Ghazanfar, Shehriyar Mehershahi, Bhavna Balar
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	liver cyst intracystic bleeding anticoagulation polycystic liver disease Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/44d2f2ef5ed14124bca17bbd8432028f
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spelling	oai:doaj.org-article:44d2f2ef5ed14124bca17bbd8432028f2021-11-04T14:40:31ZApixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication1662-063110.1159/000519276https://doaj.org/article/44d2f2ef5ed14124bca17bbd8432028f2021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519276https://doaj.org/toc/1662-0631Cystic lesions of the liver are a heterogeneous group of disorders with varied etiology, prevalence, and clinical manifestations. Fibropolycystic liver disease encompasses a spectrum of related liver and biliary tract lesions caused by abnormal embryologic development of the ductal plates. These disorders include congenital hepatic fibrosis, biliary hamartomas, polycystic liver disease (PCLD), choledochal cysts, and Carolis disease. PCLD is arbitrarily defined as a liver that contains >20 cysts. Most liver cysts are incidentally found on imaging studies, and the majority of the patients with liver cysts are asymptomatic. Rarely, complications such as compression, infection, and bleeding within the cyst can occur. Under the effect of the increased pressure, the epithelial lining of the cyst undergoes necrosis and sloughing, causing injury of the fragile blood vessels, leading to intracystic bleeding. The bleeding within or from the cyst can be precipitated by anticoagulation. We present a patient with PCLD who developed intracystic bleeding after he was started on apixaban for the prevention of thromboembolism.Elona ShehiKed FortuziHaider GhazanfarShehriyar MehershahiBhavna BalarKarger Publishersarticleliver cystintracystic bleedinganticoagulationpolycystic liver diseaseDiseases of the digestive system. GastroenterologyRC799-869ENCase Reports in Gastroenterology, Vol 15, Iss 3, Pp 904-909 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver cyst intracystic bleeding anticoagulation polycystic liver disease Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	liver cyst intracystic bleeding anticoagulation polycystic liver disease Diseases of the digestive system. Gastroenterology RC799-869 Elona Shehi Ked Fortuzi Haider Ghazanfar Shehriyar Mehershahi Bhavna Balar Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication
description	Cystic lesions of the liver are a heterogeneous group of disorders with varied etiology, prevalence, and clinical manifestations. Fibropolycystic liver disease encompasses a spectrum of related liver and biliary tract lesions caused by abnormal embryologic development of the ductal plates. These disorders include congenital hepatic fibrosis, biliary hamartomas, polycystic liver disease (PCLD), choledochal cysts, and Carolis disease. PCLD is arbitrarily defined as a liver that contains >20 cysts. Most liver cysts are incidentally found on imaging studies, and the majority of the patients with liver cysts are asymptomatic. Rarely, complications such as compression, infection, and bleeding within the cyst can occur. Under the effect of the increased pressure, the epithelial lining of the cyst undergoes necrosis and sloughing, causing injury of the fragile blood vessels, leading to intracystic bleeding. The bleeding within or from the cyst can be precipitated by anticoagulation. We present a patient with PCLD who developed intracystic bleeding after he was started on apixaban for the prevention of thromboembolism.
format	article
author	Elona Shehi Ked Fortuzi Haider Ghazanfar Shehriyar Mehershahi Bhavna Balar
author_facet	Elona Shehi Ked Fortuzi Haider Ghazanfar Shehriyar Mehershahi Bhavna Balar
author_sort	Elona Shehi
title	Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication
title_short	Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication
title_full	Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication
title_fullStr	Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication
title_full_unstemmed	Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication
title_sort	apixaban causing hepatic cystic bleeding: a rare but a life-threatening complication
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/44d2f2ef5ed14124bca17bbd8432028f
work_keys_str_mv	AT elonashehi apixabancausinghepaticcysticbleedingararebutalifethreateningcomplication AT kedfortuzi apixabancausinghepaticcysticbleedingararebutalifethreateningcomplication AT haiderghazanfar apixabancausinghepaticcysticbleedingararebutalifethreateningcomplication AT shehriyarmehershahi apixabancausinghepaticcysticbleedingararebutalifethreateningcomplication AT bhavnabalar apixabancausinghepaticcysticbleedingararebutalifethreateningcomplication
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Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication

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